Home
Acivicin (LKT Cat#: A0934) is a potent anti-cancer agent originally isolated from Streptomyces sviceus. This heterocyclic analog of L-glutamate is a potential therapeutic in the treatment of a variety of carcinomas, melanomas and leukemia.
Cancer cells, like those in leukemia, have elevated levels of glutamine amidotransferases to help supply the rapidly dividing cells with essential amino acids. Acivicin irreversibly inhibits the amidotransferase precursors from transforming to the active enzyme. It accomplishes this through nucleophillic displacement and subsequent trapping of a critical threonine residue in glutamine amidotransferase.
This acivicin mediated inactivation of the enzyme deprives the cancer cells of its supply of essential amino acids and leads to cell death.
Specifications
| Cas No. | 42228-92-2 |
| Product ID | A0934 |
| Product Name | Acivicin |
| Chemical Name | (2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid |
| Synonym | a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid; ACIA |
| Formula Wt. | 178.57 |
| Melting Point | 209oC-211oC |
| Purity | ≥98% |
| Solubility | Soluble in water. Slightly soluble in methanol, ethanol or chloroform. |
| Store Temp | -20oC |
| References | Griffith, O.W. et al. Proc. Natl. Acad. Sci. USA 77:3384 (1980). Earhart, R.H., et al. Adv. Enzyme Regulation. 24:179 (1986). Mukherjee, T. et al. Biochem. Biophys. Res. Commun. 170:426(1982). Graber, R., Losa, G.A. Int. J. Cancer. 62:443-8 (1995). |
