| T0002 |
T2 Toxin |
1 mg |
$33.60 |
| |
Insariotoxin, T2 Trichothecene |
5 mg |
$132.20 |
| |
C24H34O9 FW 466.52 [21259-20-1] |
10 mg |
$235.20 |
| |
A potent trichothecene group mycotoxin. It elicits a severe inflammatory |
|
|
| |
reaction in animals and has teratogenic effects. |
|
|
| |
Rocha O, Anasari K, Doohan FM Food Addit. Contam. 22:369-78 (2005). |
|
|
| |
|
|
|
| T0008 |
Tacrolimus |
1 mg |
$56.40 |
| |
FK506 |
5 mg |
$150.50 |
| |
C44H69NO12 FW 804.02 [104987-11-3] |
25 mg |
$608.40 |
| |
An immunosuppressant commonly used in transplant operations to prevent graft-versus-host disease. |
|
|
| |
Sawada S, Suzuki G, Kawase Y et al. J Immunol. 139:1797-1803 (1987). |
|
|
| |
|
|
|
| |
|
|
|
| T0250 |
Tamoxifen Citrate |
500 mg |
$84.00 |
| |
C26H29NO.C6H8O7 FW 563.6 [54965-24-1] |
1 g |
$149.10 |
| |
Antiestrogenic compound. It inhibits carcinogenesis and induces apoptosis in cancer cell lines. |
5 g |
$530.90 |
| |
Ueo H, Matsuoka H, Honda M et al. Cancer Lett. 71:19-24 (1993). |
|
|
| |
Moon RC, Kelloff GJ, Detrisac CJ et al. Anticancer Res. 12:1147-53 (1992). |
|
|
| |
Cadieux, R. Post Graduate Medicine. 106:6 (1999). |
|
|
| |
|
|
|
| T0251 |
Tamsulosin Hydrochloride |
10 mg |
$44.80 |
| |
C20H28N2O5S.HCl FW 444.98 m.p. 280-2900 [106463-17-6] |
25 mg |
$76.20 |
| |
An a1-adrenoceptor antagonist used to treat benign prostatic hypertrophy. |
100 mg |
$196.00 |
| |
Takenaka T, Fujikura T, Honda K et al. Yakugaku Zasshi. 115:773-89 (1995). |
|
|
| |
|
|
|
| T0152 |
Tandutinib |
1 mg |
$48.00 |
| |
C31H42N6O4 FW 562.70 [387867-13-2] |
5 mg |
$228.00 |
| |
A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic |
25 mg |
$915.00 |
| |
activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like |
|
|
| |
Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, |
|
|
| |
thereby inhibiting cellular proliferation and inducing apoptosis. |
|
|
| |
Brownlow, N. Leukemia (2008), 22(7), 1452-1453. |
|
|
| |
2. DeAngelo, D. Blood (2006), 108(12), 3674-3681. |
|
|
| |
|
|
|
| T0153 |
Tanshinone I |
10 mg |
$91.20 |
| |
C18H16O3 FW 280.32 [568-73-0] |
25 mg |
$197.30 |
| |
Tanshinones are pigments isolated from the herbal medicine Salvia miltiorrhiza |
100 mg |
$637.50 |
| |
BUNGE. Tanshinone I was found to have cytotoxicity against human macrophages |
|
|
| |
and IFN-g production in KLH-primed lymph node cells. |
|
|
| |
Li ZT, Yang BJ, Ma GE. Acta Pharm Sinica. 26:209-213 (1991). |
|
|
| |
Ryu SY, Lee CO, Choi SU, Planta Medica. 63:339-342 (1997). |
|
|
| |
Kang BY, Chung SW, Kim SH et. al. Immunopharm. 49:355-361 (2000). |
|
|
| |
|
|
|
| T0154 |
Tanshinone IIA |
10 mg |
$91.20 |
| |
C19H18O3 FW 294.34 [568-72-9] m.p. 198-2000C |
25 mg |
$197.30 |
| |
Tanshinone IIA is one of the active ingredients isolated from the roots of the |
100 mg |
$637.50 |
| |
Chinese medicinal plant, Salvia miltiorrhiza B. Tanshinones are cytoxic to various |
|
|
| |
human cancer cell lines. Dihydrotanshinones and others have anti-allergic activity in in vitro studies. |
|
|
| |
Sato M, Sato T, Ose Y et al. Mutat Res. 265:149-154 (1992). |
|
|
| |
Wu WL, Chang WL, Chen CF. Am J Chin Med. 19:207-216 (1991). |
|
|
| |
Ryu SY, Lee CO, Choi SU. Planta Med. 63:339-342 (1997). |
|
|
| |
Ryu SY. Oak MH, Kim KM. Planta Med. 65:654-655 (1999). |
|
|
| |
|
|
|
| T0076 |
TAT |
0.5 mg |
$64.50 |
| |
C64H119N33O13 FW 1558.88 |
1 mg |
$109.30 |
| |
A transcriptional transactivator protein essetial for HIV-1 viral replication. |
2.5 mg |
$193.50 |
| |
It also stimulates the transcription of intergratded provirus. |
|
|
| |
Liou L, Herrmann CH, Rice AP. J Virol. 76: 10579-10587 (2002). |
|
|
| |
|
|
|
| T0077 |
TAT 2-4 |
0.5 mg |
$53.80 |
| |
C132H240N66O29 FW 3215.81 |
1 mg |
$91.80 |
| |
|
2.5 mg |
$161.30 |
| |
|
|
|
| T0081 |
Taurine |
50 g |
$41.10 |
| |
2-Aminoethanesulfonic acid |
100 g |
$74.60 |
| |
C2H7NO3S FW 125.15 m.p. 3000C [107-35-7] |
|
|
| |
Inhibits diethylnitrosamine and phenobarbital-induced heptocarcinogenesis. |
|
|
| |
Okamoto, K., Sugie, S., Ohnishi, M et al. Jpn J Cancer Res. 87:30-36 (1996). |
|
|
| |
|
|
|
| |
Taxanes: (Taxol (Please see Paclitaxel) |
|
|
| |
|
|
|
| T0093 |
2'-Acetyltaxol |
5 mg |
$227.70 |
| |
C49H53O15 FW 895.4 [92950-40-8] |
10 mg |
$353.20 |
| |
|
25 mg |
$689.90 |
| |
|
|
|
| T0094 |
2',7-bis Acetyltaxol |
5 mg |
$236.60 |
| |
C51H55NO16 FW 938.0 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| T0109 |
13-Acetyl-9-Dihydrobaccatin-III |
5 mg |
$236.60 |
| |
C33H44O12 FW 630.68 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0092 |
1-Hydroxy Baccatin I |
5 mg |
170 |
| |
C32H44O13 FW 636.88 |
10 mg |
295.7 |
| |
|
25 mg |
591.4 |
| |
|
|
|
| |
|
|
|
| T0095 |
Baccatin III |
5 mg |
$162.70 |
| |
C31H39O11 FW 586.63 [27548-93-2] |
10 mg |
$295.70 |
| |
|
25 mg |
$591.40 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0117 |
Benzyl Analog of Taxol |
1 mg |
$295.70 |
| |
C48H53NO14 FW 867.93 |
5 mg |
$1,005.40 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0096 |
Cephalomannine |
5 mg |
$162.70 |
| |
C45H53NO14 FW 831.9 [71610-00-9] |
10 mg |
$295.70 |
| |
|
25 mg |
$591.40 |
| |
|
|
|
| |
|
|
|
| T0118 |
7-epi-Cephalomannine |
5 mg |
$414.00 |
| |
C45H53NO14 FW 831.9 |
10 mg |
$709.70 |
| |
|
25 mg |
$1,182.70 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0099 |
10-Deacetylbaccatin-III |
5 mg |
$236.60 |
| |
C29H36NO10 FW 544.60 [32981-86-5] |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0100 |
10-Deacetyl taxol |
5 mg |
$236.60 |
| |
C45H49NO13 FW 811.87 |
10 mg |
$378.50 |
| |
|
25 mg |
$813.10 |
| |
|
|
|
| T0101 |
7-epi-10-Deacetyltaxol |
5 mg |
$236.60 |
| |
C45H49NO13 FW 811.87 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0097 |
10-Deacetyltaxol-B (10-Deacetylcephalomannine) |
5 mg |
$236.60 |
| |
C43H51NO13 FW 789.86 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0098 |
10-Deacetyltaxol-C |
5 mg |
$236.60 |
| |
C45H55NO13 FW 817.92 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0108 |
10-Deacetyl-7-xylosyltaxol, 90% |
5 mg |
$295.70 |
| |
C50H57NO17 FW 943.98 |
10 mg |
$473.20 |
| |
|
25 mg |
$887.00 |
| |
|
|
|
| |
|
|
|
| T0116 |
2",3"-Dihydrocephalomannine |
5 mg |
$414.00 |
| |
C45H55NO14 FW 833.92 |
10 mg |
$709.70 |
| |
|
25 mg |
$1,182.70 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0102 |
7-epi-Taxol |
5 mg |
$236.60 |
| |
C47H51NO14 FW 853.91 [105454-04-4] |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0115 |
Taxol side chain acid |
5 mg |
$170.00 |
| |
C16H15NO4 FW 285.29 |
10 mg |
$295.70 |
| |
|
25 mg |
$591.40 |
| |
|
|
|
| |
|
|
|
| T0103 |
Taxol-side chain diol |
5 mg |
$170.00 |
| |
C16H17NO3 FW 271.31 |
10 mg |
$295.70 |
| |
|
25 mg |
$591.40 |
| |
|
|
|
| T0104 |
Taxol-side chain methyl ester |
5 mg |
$170.00 |
| |
C17H17NO4 FW 299.32 |
10 mg |
$295.70 |
| |
|
25 mg |
$591.40 |
| |
|
|
|
| T0119 |
Taxol-side chain b-lactam |
5 mg |
$151.80 |
| |
(3R,4S) -3-(acetyloxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid |
10 mg |
$264.00 |
| |
1,1-dimethylethyl ester |
25 mg |
$528.00 |
| |
C16H19NO5 FW 305.33 [161183-22-8] |
|
|
| |
Intermediate for the semi-synthesis of various taxanes. |
|
|
| |
|
|
|
| T0105 |
Taxol C |
5 mg |
$236.60 |
| |
C47H57NO14 FW 859.95 |
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0090 |
7-(triethylsilyl)-Baccatin III |
5 mg |
$236.60 |
| |
C37H52O11Si FW 700.89 |
10 mg |
$378.50 |
| |
Intermediate for the semi-synthesis of various taxanes. |
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0091 |
7-(triethylsilyl)-10-deacetyl Baccatin III |
5 mg |
$236.60 |
| |
C35H50O10Si FW 658.85 |
10 mg |
$378.50 |
| |
Intermediate for the semi-synthesis of various taxanes. |
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0106 |
Xylosyltaxol, 90% |
5 mg |
$309.70 |
| |
|
10 mg |
$496.80 |
| |
|
25 mg |
$967.70 |
| |
|
|
|
| |
|
|
|
| T0107 |
Xylosyltaxol C, 90% |
5 mg |
$236.60 |
| |
|
10 mg |
$378.50 |
| |
|
25 mg |
$739.20 |
| |
|
|
|
| |
|
|
|
| T0110 |
Taxanes Standards Mixture |
500 µl |
$455.40 |
| |
A mixture of 13 different taxanes at a concentration of 50 µg/ml in |
|
|
| |
methanol and 0.1% acetic acid. |
|
|
| |
10-deacetylbaccatin III, Baccatin III, 10 deacetyl-7-xylosyltaxol B, Taxinine M, |
|
|
| |
10 deacetyl 7 zylosyltaxol, 10 deacetyl 7 xylosyltaxol C, 10 deaceytltaxol, |
|
|
| |
7-Xylosyltaxol, Cephalomannine, 10-deacetyl-7-epitaxol, Paclitaxel, |
|
|
| |
Taxol C, 7-epi taxol. |
|
|
| |
|
|
|
| T0114 |
Taxinine M |
5 mg |
$295.70 |
| |
C35H42O14 FW 686.70 |
10 mg |
$473.20 |
| |
|
25 mg |
$887.00 |
| |
|
|
|
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T0298 |
Tazobactam |
100 mg |
$57.50 |
| |
Free acid |
500 mg |
$216.60 |
| |
C10H12N4O5S FW 300.29 [89786-04-9] |
1 g |
$393.50 |
| |
A beta-lactamase inhibitor antibacterial. |
|
|
| |
Bryson HM, Brogden RN. Drugs. 47:506-35 (1994). |
|
|
| |
|
|
|
| T0299 |
Tazobactam sodium |
100 mg |
$57.50 |
| |
C10H11N4NaO5S FW 322.274 [89785-84-2] |
500 mg |
$216.60 |
| |
A beta-lactamase inhibitor antibacterial. |
1 g |
$393.50 |
| |
Bryson HM, Brogden RN. Drugs. 47:506-35 (1994). |
|
|
| |
|
|
|
| T1298 |
TDZD-8 NEW PRICE! |
5 mg |
$75.00 |
| |
C10H10N2O2S FW 222.26 [327036-89-5] |
25 mg |
$295.00 |
| |
An inhibitor of glycogen synthase kinase-3 (GSK3) beta, which was found to be a key intermediate |
|
|
| |
in apoptotic signaling associated with neurodegenerative diseases such as Parkinsons'. |
|
|
| |
Chen G, Bower KA, Ma C et al. FASEB J. 18:1162-1164 (2004). |
|
|
| |
Barry FA, Graham GJ, Fry MJ et al. FEBS letters. 553:173-178 (2003). |
|
|
| |
|
|
|
| T1605 |
Tebuconazole |
5 g |
$33.60 |
| |
C16H22ClNO3O FW 307.82 [107534-96-3] |
10 g |
$50.40 |
| |
Is a triazole fungicide used agriculturally to treat plant pathogenic fungi. It is |
100 g |
$196.00 |
| |
listed as a potential carcinogen by the EPA. |
|
|
| |
Zhang, S. Faming Zhuanli Shenqing Gongkai Shuomingshu (2008), |
|
|
| |
|
|
|
| |
Tegafur (See Ftorafur) |
|
|
| |
|
|
|
| T1644 |
Telmisartan |
50 mg |
$78.70 |
| |
C33H30N4O2 FW 514.62 [144701-48-4] |
100mg |
$123.00 |
| |
A nonpeptide angiotensin II receptor antagonist which inhibits the |
500 mg |
$450.90 |
| |
angiotensin II AT1 receptor. |
|
|
| |
McClellan KJ, Markham A. Drugs. 56:1039-44 (1998). |
|
|
| |
|
|
|
| T1750 |
Temocapril Hydrochloride |
10 mg |
$67.20 |
| |
C23H28N2O5S2.HCl FW 513.07 [110221-44-8] |
25 mg |
$123.20 |
| |
Is an ACE inhibitor (angiotensin converting enzyme). Pro-drug that is converted |
100 mg |
$392.00 |
| |
in vivo to treat hypertension. |
|
|
| |
Shionoiri, H. Cardiac Practice (1995), 6(4), 487-94. |
|
|
| |
|
|
|
| T1849 |
Temozolomide |
25 mg |
$103.50 |
| |
C6H6N6O2 FW 194.15 [85622-93-1] |
100 mg |
$310.50 |
| |
An alkylating antitumor agent that has antiangiogenic activity |
500 mg |
$1,241.90 |
| |
and induces apoptosis in cell cultures. |
|
|
| |
Tisdale MJ. Biochem Pharmacol. 36:457-62 (1987). |
|
|
| |
Kurzen H, Schmitt S, Naher H, Mohler T. Anticancer Drugs. 14:515-22 (2003). |
|
|
| |
Gunther W, Pawlak E, Damasceno R et al. Br J Cancer. 88:463-9 (2003). |
|
|
| |
|
|
|
| T1754 |
Tenatoprazole Monosodium |
100 mg |
$48.40 |
| |
C16H17N4S.Na FW 369.40 [113712-98-4] |
500 mg |
$144.90 |
| |
A proton pump inhibitor. |
1 g |
$231.80 |
| |
Nakamura T, Nippon Rinsho. 60 Suppl. 2:650-4 (2002). |
|
|
| |
|
|
|
| T1652 |
Teniposide |
25 mg |
$65.60 |
| |
C32H32O13S FW 656.65 [29767-20-2] |
100 mg |
$221.30 |
| |
A derivative of the cytotoxic natural product, epipodophyllotoxin, acts on |
500 mg |
$819.70 |
| |
topoisomerase II that results in DNA strand breaks. |
|
|
| |
Ross W, Rowe T, Glisson B, Yalowich J, Liu L. Cancer Res. 44:5857-60 (1984). |
|
|
| |
|
|
|
| T1654 |
Tenoxicam |
250 mg |
$34.90 |
| |
C13H11N3O4S2 FW 337.38 [59804-37-4] |
1 g |
$91.20 |
| |
Nonsteroidal anti-inflammmatory, analgesic agent.Found to have antitumor effects. |
5 g |
$303.60 |
| |
Giordano V, Giordano M, Knackfuss IG et al. Injury 34:85-94 (2003). |
|
|
| |
Sakusabe N, Okada K, Sato K et al. Jpn J Cancer Res. 90:1146-51 (1999). |
|
|
| |
|
|
|
| T1670 |
Terazosin Hydrochloride dihydrate |
50 mg |
$69.00 |
| |
C19H25N5O4.HCl.2H2O FW 423.93 [70024-40-7] |
250 mg |
$276.00 |
| |
An a1-selective blocker. Its inhibitory effect on prostate tumor growth may be |
1 g |
$827.90 |
| |
the result of antiangiogenic activity. |
|
|
| |
Kyncl JJ. J Clin Pharmacol. 33:878-83 (1993). |
|
|
| |
Pan SL, Guh JH, Huang YW et al. J Urol. 169:724-9 (2003). |
|
|
| |
|
|
|
| T1672 |
Terbinafine Hydrochloride |
1 g |
$69.00 |
| |
C21H25N.HCl FW 327.90 [78628-80-5] |
5 g |
$276.00 |
| |
An antimicrobial agent. It was recently found to have anticancer |
10 g |
$482.90 |
| |
properties in human cancer cell lines. |
|
|
| |
Lee WS. Chen RJ. Wang YJ et al Int J Cancer. 106:125-37 (2003). |
|
|
| |
Petranyi G, Ryder NS, Stutz A. Science. 224:1239-41 (1984). |
|
|
| |
|
|
|
| T1674 |
Terbutaline |
1 g |
$39.20 |
| |
C12H19NO3 FW 225.28 [23031-25-6] |
5 g |
$162.40 |
| |
A beta-adrenoceptor agonist used to treat asthma and premature labor. |
|
|
| |
Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. Toxicol Appl Pharmacol. 203:132-44 (2005). |
|
|
| |
|
|
|
| T1675 |
Teriparatide Acetate |
Please inquire |
|
| |
C181H291N55O51S2 FW 4117.72 [52232-67-4] |
|
|
| |
A synthetic peptide that consists the 1-34 amino acid fragment of human parathyroid hormone. |
|
|
| |
It stimulates new bone formation, repairs structural defects and reduces risks of fractures in |
|
|
| |
postmenauposal women with severe osteoporosis. |
|
|
| |
Yodfat Y. Harefuah. 146:134-9, 164 (2007). |
|
|
| |
|
|
|
| T1673 |
Terlipressin Acetate |
1 mg |
$56.00 |
| |
C52H74N16O15S2 FW 1227.37 [14636-12-5] |
5 mg |
$196.00 |
| |
In humans, the anabolic effects of teriparatide are manifest as an increase in skeletal mass, |
|
|
| |
an increase in markers of bone formation and resorption, and an increase in bone strength. |
|
|
| |
|
|
|
| T1677 |
Tetracycline |
10 g |
$26.00 |
| |
C22H24N2O8 FW 444.43 [60-54-8] |
25 g |
$41.10 |
| |
It is used in the treatment of chronic inflammatory cells. Tetracycline derivatives |
100 g |
$118.50 |
| |
induce apoptosis in osteoclasts, Jurkat T lymphocyte cells and in cultured monocytes |
|
|
| |
and macrophages. |
|
|
| |
Bettany JT, Peet NM, Wolowacz RG et al. Bone. 27:75-80 (2000). |
|
|
| |
Liu J, Kuszynski CA, Baxter BT. Biochem Biophys Res Commun. 260:562-7 (1999). |
|
|
| |
Bettany JT, Wolowacz RG. Adv dent Res. 12: 136-43 (1998). |
|
|
| |
|
|
|
| T1679 |
Tetracycline Hydrochloride |
1 g |
$19.20 |
| |
C22H24N2O8.HCl FW 480.90 [64-75-5] |
5 g |
$30.50 |
| |
Antimicrobial agent. Tetracycline-controlled antisense bcl-2 expression induce |
25 g |
$103.50 |
| |
apoptosis in human neuroblastoma cell line SK-N_MC. |
|
|
| |
Atrasheuskaya AV, Fredeking TM, Ignatyev GM. Clin Exp Immunol. 131:148-154 (2003). |
|
|
| |
Guan J, Chen J, Zhao H. Zhonghua Bing Li Xue Za Zhi. 31:135-139 (2002). |
|
|
| |
|
|
|
| T1676 |
L-Tetrahydropalmatine Hydrochloride |
100 mg |
$32.90 |
| |
C21H25NO4.HCl FW 391.89 [10097-84-4] |
500 mg |
$118.30 |
| |
An alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters |
|
|
| |
such as dopamine, noradrenaline and serotonin. |
|
|
| |
Liu GQ, Algeri S, Garattini S. Arch Int Pharmacodyn Ther. 258:39-50 (1982). |
|
|
| |
Lin MT, Chueh FY, Hsieh MT, Chen CF. Clin Exp Pharmacol Physiol. 23:738-42 (1996). |
|
|
| |
|
|
|
| T1678 |
D,L-Tetrahydropalmatine Sulfate |
100 mg |
$41.10 |
| |
C21H25NO4.H2SO4 FW 453.50 |
500 mg |
$150.90 |
| |
An alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters |
|
|
| |
such as dopamine, noradrenaline and serotonin. |
|
|
| |
Liu GQ, Algeri S, Garattini S. Arch Int Pharmacodyn Ther. 258:39-50 (1982). |
|
|
| |
Lin MT, Chueh FY, Hsieh MT, Chen CF. Clin Exp Pharmacol Physiol. 23:738-42 (1996). |
|
|
| |
|
|
|
| T1777 |
Tetrandrine |
100 mg |
$34.50 |
| |
C38H42N2O6 FW 622.75 [518-34-3] |
500 mg |
$93.90 |
| |
A bisbenzylisoquinoline alkaloid, purified from chinese medicinal herb. It acts as |
1 g |
$144.90 |
| |
an immuno suppressant and a Ca+2 channel blocker. Tetrandrine also induces apoptotic |
|
|
| |
cell death in human leukemic U397 and human leukemic HL-60 cells. |
|
|
| |
Lai YL, Chen YJ, Wu TY et al. Anticancer Drugs. 9:77-81 (1998). |
|
|
| |
Dong Y, Yang MM, Kwan CY. Life Sci. 60:135-40 (1997). |
|
|
| |
|
|
|
| T2800 |
Thalidomide |
100 mg |
$86.10 |
| |
C13H10N2O4 FW 258.23 [50-35-1] |
250 mg |
$137.80 |
| |
Highly teratogenic compound associated with fetal abnormalities. Recently |
500 mg |
$172.10 |
| |
found to have antiangiogenic and antitumor activities. |
|
|
| |
Fratta ID et al. Toxicol Appl Pharmacol 7:268 (1965). |
|
|
| |
D'Amato J, Loughnan MS, Flynn E, Folkman J. Proc Natl Acad Sci USA. 91:4082-5 (1994). |
|
|
| |
Eisen T, Boshoff C, Mak I et al. Br J Cancer. 82:812-7 (2000). |
|
|
| |
|
|
|
| T2801 |
Thapsigargin |
1 mg |
$93.50 |
| |
C34H50O12 FW 650.75 [67526-95-8] |
5 mg |
$372.50 |
| |
A cell permeable intracellular calcium releaser and tumor promoter. |
|
|
| |
Hakii H, Fujiki H, Suganuma M et al. J. Cancer Res. Clin. Oncol 111:177-181 (1986). |
|
|
| |
Takemura H, Hughes AR, Thastrup O, Putney JW. J. Biol. Chem. 264:12266-12271 (1989). |
|
|
| |
|
|
|
| T2816 |
L-Theanine |
1 g |
$38.10 |
| |
N g-Ethyl L-glutamine, L-glutamic acid g-(ethylamide) |
5 g |
$148.80 |
| |
C7H14N2O3 FW 174.20 [3081-61-6] |
25 g |
$531.30 |
| |
One of the components of green tea. It was found to decrease the blood pressure of |
|
|
| |
spontaneously hypertensive rats. It modulates the activity of several antitumor drugs. |
|
|
| |
Yokogoshi, H, Kat Y, Sagesaka YM et al. Biosci Biotech Biochem. 59:615-618 (1995). |
|
|
| |
Sugiyama T, Sadzuka Y, Nagasawa K et al. J Cancer Res. 90:775-780 (1999). |
|
|
| |
|
|
|
| T2817 |
Theophylline |
100 g |
$37.00 |
| |
C7H8N4O2 FW 180.16 [58-55-9] |
250 g |
$92.30 |
| |
An inhibitor of cyclic phosphodiesterase. Found to decrease incidence |
|
|
| |
and multiplicity of tumors in the brain, spinal cord, peripheral nerves, and kidneys. |
|
|
| |
Alexandrov VA, Bespalov VG, Petrov AS et al. Carcinogenesis. 17:1935-1939 (1996). |
|
|
| |
|
|
|
| T2930 |
Thiabendazole |
10 g |
$31.40 |
| |
C10H7N3S FW 201.25 [148-79-8] |
100 g |
$61.50 |
| |
A widely used fungicide and antihelminthal agent. Mediates Cytochrome |
500 g |
$223.30 |
| |
P450 1A1 induction. |
|
|
| |
Ogunsusi RA. Res Vet Sci. 25:251-252 (1978). |
|
|
| |
lemaire G, Delescluse C, Pralavorio M et al. Life Sci. 74:2265-2278 (2004). |
|
|
| |
|
|
|
| |
Thiamazole (See Methimazole) |
|
|
| |
|
|
|
| T2932 |
Thiamphenicol Glycinate HCl |
1 g |
$36.10 |
| |
C14H19Cl3NO6S FW 449.70 [2611-61-2] |
5 g |
$134.40 |
| |
Used in the treatment of respiratory infections. |
25 g |
$537.00 |
| |
Ferrari V. Sex Transm Dis. 11:336-9 (1984). |
|
|
| |
|
|
|
| |
|
|
|
| |
|
|
|
| T2934 |
Thiamphenicol Palmitate |
5 g |
$116.50 |
| |
C28H45Cl2NO6S FW 594.63 |
25 g |
$447.60 |
| |
Non-carcinogenic synthetic ester of thiamphenicol. |
|
|
| |
Della Bella D, Veronese M, Marca G, Franceschinis R. Arzneimittelforschung. 24:836-9 (1974). |
|
|
| |
|
|
|
| |
|
|
|
| T3031 |
Thienylbutyl Isothiocyanate |
25 mg |
$114.80 |
| |
C9H11NS2 FW 197.32 |
50 mg |
$193.30 |
| |
|
100 mg |
$323.20 |
| |
A bifunctional inhibitor of lung and colon carcinogenesis. |
500 mg |
$1,288.90 |
| |
Lam LKT, Kenney P, Bergstrom CP, Lam SH. Proc. Am. Assoc. Cancer Res. 40: 57 (1999). |
|
|
| |
|
|
|
| T3032 |
Thienyldecyl Isothiocyanate |
25 mg |
$121.70 |
| |
C15H23NS2 FW 281.48 |
50 mg |
$204.40 |
| |
|
100 mg |
$331.30 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,303.30 |
| |
|
|
|
| T3033 |
Thienyldodecyl Isothiocyanate |
25 mg |
$147.10 |
| |
C17H27NS2 FW 309.54 |
50 mg |
$264.10 |
| |
|
100 mg |
$473.00 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,781.20 |
| |
|
|
|
| T3034 |
Thienylethyl Isothiocyanate |
25 mg |
$61.90 |
| |
C7H7NS2 FW 169.27 |
50 mg |
$112.10 |
| |
|
100 mg |
$197.10 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$805.60 |
| |
|
|
|
| T3035 |
Thienylheptyl Isothiocyanate |
10 mg |
$117.40 |
| |
C12H17NS2 FW 239.40 |
25 mg |
$265.00 |
| |
|
50 mg |
$474.50 |
| |
An analog of thienylbutyl isothiocyanate. |
100 mg |
$814.70 |
| |
|
|
|
| T3036 |
Thienylhexyl Isothiocyanate |
25 mg |
$116.50 |
| |
C11H15NS2 FW 225.38 |
50 mg |
$197.10 |
| |
|
100 mg |
$322.30 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,288.90 |
| |
|
|
|
| T3037 |
Thienylmethyl Isothiocyanate |
100 mg |
$54.80 |
| |
C6H5NS2 FW 155.24 |
500 mg |
$223.70 |
| |
|
1 g |
$394.00 |
| |
An analog of thienylbutyl isothiocyanate. |
|
|
| |
|
|
|
| T3038 |
Thienylnonanyl Isothiocyanate |
25 mg |
$147.10 |
| |
C14H21NS2 FW 267.46 |
50 mg |
$264.10 |
| |
|
100 mg |
$473.00 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,781.20 |
| |
|
|
|
| T3039 |
Thienyloctyl Isothiocyanate |
25 mg |
$129.10 |
| |
C13H19NS2 FW 253.43 |
50 mg |
$200.60 |
| |
|
100 mg |
$325.90 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,297.90 |
| |
|
|
|
| T3040 |
Thienylpentyl Isothiocyanate |
25 mg |
$121.70 |
| |
C10H13NS2 FW 211.35 |
50 mg |
$204.40 |
| |
|
100 mg |
$331.30 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,303.30 |
| |
|
|
|
| T3041 |
Thienylpropyl Isothiocyanate |
25 mg |
$121.70 |
| |
C8H9NS2 FW 183.30 |
50 mg |
$204.40 |
| |
|
100 mg |
$331.30 |
| |
An analog of thienylbutyl isothiocyanate. |
500 mg |
$1,303.30 |
| |
|
|
|
| T3133 |
Thioctic Acid |
5 g |
$62.90 |
| |
C8H14O2S2 FW 206.33 [62-46-4] |
10 g |
$107.50 |
| |
Growth factor for bacteria; prosthetic group, coenzyme or substrate in plants and |
25 g |
$241.80 |
| |
animals. Occurs naturally in the (d) conformation. It has antioxidant and neuroprotecitve effects. |
|
|
| |
Packer L, Tritschler HJ, Wessel K. Free Radic Biol Med. 22:359-78 (1997). |
|
|
| |
|
|
|
| T2833 |
1-Thio-b-D-glucose tetraacetate |
250 mg |
$25.30 |
| |
C14H20O9S FW 364.4 [19879-84-6] |
1 g |
$75.30 |
| |
|
|
|
| |
|
|
|
| T2835 |
6-Thioguanine |
250 mg |
$31.40 |
| |
C5H5N5S Mol. Wt: 167.19 [154-42-7] |
500 mg |
$50.40 |
| |
A chemotherapy drug that demonstrates anti-neoplastic, immunosuppressive |
1 g |
$78.40 |
| |
and anti-cancer activities. 6-Thioguanine is often used to treat inflammatory |
|
|
| |
diseases and leukemia. |
|
|
| |
Karran P. Br Med Bull 79-80: 153-70 (2006). |
|
|
| |
Sartorelli AC, Booth BA. Cancer Res. 25: 1393-40 (1965). |
|
|
| |
|
|
|
| T2834 |
Thiolutin |
1 mg |
$44.80 |
| |
C8H8N2O2S2 FW 228.29 [87-11-6] |
5 mg |
$134.40 |
| |
A sulfur containing antibiotic which is a potent inhibitor of RNA polmerase. |
10 mg |
$240.80 |
| |
Inhibits adhesion of human umbilical vein endothelial cells and thereby suppresses |
|
|
| |
tumor cell induced angiogenesis |
|
|
| |
Kebaara, B. W. Genome (2006), 49(8), 894-899. |
|
|
| |
|
|
|
| T2933 |
4-Thiouridine |
5 mg |
$26.80 |
| |
C9H12N2O5S FW 260.27 m.p. 141-1430C [13957-31-8] |
25 mg |
$65.20 |
| |
Thionucleobase, used as antisense agent. |
100 mg |
$210.60 |
| |
Testa SM, Disney MD, Turner DH, Kierzek R. Biochemistry 38:16655-62 (1999). |
250 mg |
$426.00 |
| |
|
|
|
| T2970 |
Thrombin Receptor Agonist |
1 mg |
$129.00 |
| |
C81H118N20O23 FW 1739.96 [137339-65-2] |
2 mg |
$218.60 |
| |
A synthetic peptide that mimics the effects of thrombin, activates proteaase |
5 mg |
$387.10 |
| |
activated receptor-1 in wounds of mice. |
|
|
| |
Strukova SM, Dugina TN, and Chistov IV et. al.Clin Appl Thromb Hemost. 7: 325-9 (2001). |
|
|
| |
|
|
|
| T3093 |
Thymopentin |
5 mg |
$107.50 |
| |
C30H49N9O9 FW 679.8 |
10 mg |
$182.80 |
| |
A synthetic peptide corresponding to the 32-36 amino acid fragment of |
25 mg |
$322.60 |
| |
thymopoietin. It exhibits biological fuctions like the natural hormone including |
|
|
| |
T-cells differentiation and immune systems regulation. |
|
|
| |
Onoue S, Liu B, Nemoto Y, Hirose M, Yajima T. Anal Sci. 22:1531-5 (2006). |
|
|
| |
|
|
|
| T3094 |
Thymopentin Acetate (TP-5) |
10 mg |
$60.30 |
| |
C30H49N9O9.CH3.COOH FW 739.8 |
50 mg |
$261.00 |
| |
A synthetic immunomodulating pentapeptide, found to increase the number of |
1 g |
$963.40 |
| |
cells undergoing apoptosis in irradiated cells and selectively bind to apoptotic cells. |
|
|
| |
Gonser S, Crompton NE, Folkers G et al. Mutat Res. 558:19-26 (2004). |
|
|
| |
Gonser S, Weber E, Folkers G. Pharm Acta Helv. 73:265-73 (1999). |
|
|
| |
|
|
|
| T3096 |
Thymosin a-1 |
10 mg |
$448.00 |
| |
C129H215N33O55 FW 3108.3 [62304-98-7] |
50 mg |
$1,433.60 |
| |
An immunomodulating thymic peptide that has been used for the treatment of |
1g |
$5,376.00 |
| |
chronic hepatitis B viral infection. It has been shown to activate tumor-associated |
|
|
| |
macrophages to a tumoricidal state in a murine model. |
|
|
| |
Shrivastava P, Singh SM, Singh N. J Biomed Sci. 11:623-30 (2004). |
|
|
| |
Li CL, Zhang T, Saibara T et al. Int Immunopharmacol. 2:39-46 (2002). |
|
|
| |
|
|
|
| T3097 |
Thymosin a-1 Acetate |
Please inquire |
|
| |
C129H215N33O55 FW 3108.3 [62304-98-7] |
|
|
| |
Thymosin a1 has immunoregulatory properties enhancing immune functions. |
|
|
| |
For the treatment of hepatitis B and C. |
|
|
| |
|
|
|
| T3098 |
Thymosin b-4 Acetate |
Please inquire |
|
| |
C212H350N56O78S FW 4963.49 [77591-33-4] |
|
|
| |
An actin-sequestering peptide that modulates inflammation and healing in different tissues. |
|
|
| |
It plays a major role in angiogenesis and tumor metastasis. |
|
|
| |
Moon HS, Even-Ram S, Kleinman HK, Cha HJ. Exp Cell Res. 312: 3425-31 (2006). |
|
|
| |
Larsson LI, Holck S. Hum Pathol. 38: 114-9 (2007). |
|
|
| |
|
|
|
| T3099 |
Thymus Factor |
1 mg |
$35.80 |
| |
C33H57N13O15 FW 875.9 |
2 mg |
$60.90 |
| |
A thymic peptide hormone. |
5 mg |
$107.50 |
| |
|
|
|
| T3100 |
Thyrotropin-Releasing Hormone (TRH) |
5 mg |
$35.80 |
| |
C16H23NO FW 363.4 |
10 mg |
$60.90 |
| |
The final precursor for TRH formation. It signals through a G protein-coupled |
25 mg |
$107.50 |
| |
receptor. |
|
|
| |
Laakkonen L, Li W, Perlman JH, and Guarnieri F. et. al.Mol Pharmacol. 49: 1092-6 (1996). |
|
|
| |
|
|
|
| T3197 |
L-Thyroxine Sodium Salt Pentahydrate |
1 g |
$84.00 |
| |
C15H10I4NNaO4.5H2O FW 888.93 [6106-07-6] |
5 g |
$319.20 |
| |
A thyroid hormone involved in controlling the rate of metabolic processes. |
|
|
| |
Udupa, A. Indian Journal of Experimental Biology (1976), 14(1), 14-18. |
|
|
| |
|
|
|
| T3101 |
TRH, Free Acid |
5 mg |
$35.80 |
| |
C16H21N5O5 FW 363.4 |
10 mg |
$60.90 |
| |
|
25 mg |
$107.50 |
| |
|
|
|
| T3305 |
Tibolone |
100 mg |
$138.00 |
| |
C21H28O2 FW 312.45 [5630-53-5] |
500 mg |
$517.40 |
| |
A synthetic normethyl testosterone derivative used in the prevention of |
1 g |
$827.90 |
| |
postmenopausal osteoporosis. It is capable of inducing apoptosis in breast cancer cell lines. |
|
|
| |
Coope J. Br Med J. 281:456-7 (1980). |
|
|
| |
Kandouz M, Lombet A, Perrot JY et al. J Steroid Biochem Mol Biol. 69:463-71 (1999). |
|
|
| |
|
|
|
| T3310 |
Ticlopidine Hydrochloride |
1 g |
$23.50 |
| |
C14H14ClNS.HCl FW 300.25 [53885-35-1] |
5 g |
$69.00 |
| |
A platelet aggregation inhibitor capable of inducing apoptosis in various cancer |
25 g |
$255.40 |
| |
cell lines. Its effects on platelet aggregation may be the result of inhibition of VEGF. |
|
|
| |
Chen WH, Yin HL, Chang YY et al. Kaohsiung J Med Sci. 13:589-97 (1997). |
|
|
| |
Ma L, Elliott SN, Cirino G et al. Proc Natl Acad Sci U S A. 98:6470-5 (2001). |
|
|
| |
|
|
|
| T3350 |
Timolol Maleate |
100 mg |
$41.40 |
| |
C13H24N4S.C4H4O4 FW 432.50 [26921-17-5] |
250 mg |
$89.70 |
| |
A b-adrenergic receptor selective antagonist used as a antiglaucoma agent. |
1 g |
$248.40 |
| |
Hall RA, Robson RD, Share NN. Arch Int Pharmacodyn Ther. 213:251-63 (1975). |
|
|
| |
Feghali JG, Kaufman PL, Radius RL et al. Acta Ophthalmol (Copenh). 66:180-6 (1988). |
|
|
| |
|
|
|
| T3454 |
Tinidazole |
100 g |
$62.20 |
| |
C8H13N3O4S FW 247.27 [19387-91-8] |
250 g |
$135.30 |
| |
A synthetic imidazole derivative used in antiprotozoal treatment. |
|
|
| |
Sawyer PR, Brogden RN, Pinder RM et al. Drugs. 11:423-40 (1976). |
|
|
| |
|
|
|
| T3354 |
Tinyatoxin (TYX) |
1 mg |
$151.50 |
| |
C36H38O8 FW 598.70 [58821-95-7] |
5 mg |
$616.30 |
| |
Analog of resiniferatoxin (RTX). It is less potent as an irritant than RTX. |
|
|
| |
It is more stable against air oxidation than RTX. |
|
|
| |
Geiges D, Meyer T, Marte B et al. Biochem Pharmacol. 53:865-75 (1997). |
|
|
| |
|
|
|
| T3357 |
Tioconazole |
1 g |
$42.60 |
| |
C16H13Cl3N2OS FW 387.71 [65899-73-2] |
5 g |
$88.10 |
| |
Antifungal agent. Potent inhibitor of cytochrome-P450. |
25 g |
$425.00 |
| |
Somchit MN, Reezal I, Nur IE, Mutalib AR. J Ethnopharmacol. 84:1-4 (2003). |
|
|
| |
Alvarez J, Montero M, Garcia-Sancho J. J Biol Chem. 267:11789-11793 (1992). |
|
|
| |
|
|
|
| |
Tioguanine (See thioguanine) |
|
|
| |
|
|
|
| T5604 |
Tobramycin (free base) |
25 mg |
$29.50 |
| |
C18H37N5O9 FW 467.51 [32986-56-4] |
100 mg |
$65.60 |
| |
Used in the treatment of respiratory infection and cystic fibrosis. |
500 mg |
$286.90 |
| |
Brogden RN, Pinder RM, Sawyer PR. Drugs. 12:166-200 (1976). |
|
|
| |
|
|
|
| T5605 |
Tobramycin Sulfate |
100 mg |
$44.90 |
| |
(C18H37N5O9)2.5H2SO4 FW 1425.45 [79645-27-5] |
500 mg |
$152.20 |
| |
Used in the treatment of respiratory infection and cystic fibrosis. |
1 g |
$268.60 |
| |
Brogden RN, Pinder RM, Sawyer PR. Drugs. 12:166-200 (1976). |
|
|
| |
|
|
|
| T5846 |
Tolfenamic Acid |
5 g |
$42.60 |
| |
C14H12ClNO2 FW 261.70 [13710-19-5] |
25 g |
$139.70 |
| |
Non steroidal anti-inflammatory agent. Found to inhibit COX-2 isoenzymes in |
50 g |
$227.70 |
| |
dogs. Analgesic property is due to activation of Ca2+-activated K+ channels. |
|
|
| |
Kay-Mugford P, Benn SJ, LaMarre J, Conlon P. Am J Vet Res. 61:802-810 (2000). |
|
|
| |
Li L, Vaali K Vapaatalo H, Kankaanranta H. Eur J Pharmacaol. 383:169-176 (1999). |
|
|
| |
|
|
|
| T5944 |
Tolmetin Sodium |
1 g |
$21.30 |
| |
C15H14NNaO3.2H2O FW 315.30 [64490-92-2] |
5 g |
$60.80 |
| |
Anti-inflammatory, antirheumatic agent. |
25 g |
$220.20 |
| |
Lewis JR. JAMA 237:1260-1261 (1997). |
|
|
| |
|
|
|
| T5946 |
Toltrazuril |
1 g |
$48.40 |
| |
C18H14F3N3O4S FW 425.38 [69004-03-1] |
5 g |
$200.10 |
| |
An anticoccidial agent. Its mode of action appears to be a reduction of redox |
10 g |
$358.80 |
| |
enzymes such as succinate-cytochrome C reductase and NADH oxidase and fumarate oxidase. |
|
|
| |
Harder A, Haberkorn A, Parasitol Res. 76:8-12 (1989). |
|
|
| |
|
|
|
| |
Tomoxetine Hydrochloride (See Atomoxetine Hydrochloride) |
|
|
| |
|
|
|
| T5761 |
Topotecan Hydrochloride |
1 mg |
$116.50 |
| |
C23H23N3O5.HCl FW 459.91 [119413-54-6] |
5 mg |
$492.20 |
| |
Topoisomerase I inhibitor that is a water soluble semisynthetic camptothecin derivative. |
|
|
| |
Rothenberg ML. Ann Oncol. 8:837-55 (1997). |
|
|
| |
|
|
|
| |
|
|
|
| T5769 |
Toremifene |
500 mg |
$43.10 |
| |
C26H28ClNO FW 405.96 [89778-26-7] |
1 g |
$68.90 |
| |
A chlorinated tamoxifen analogue. It competes with estradiol for estrogen |
5 g |
$258.20 |
| |
receptors and has growth inhibitory effects on MCF-7 breast cancer cells. It causes |
|
|
| |
growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to |
|
|
| |
undergo apoptosis and by inhibiting other cells from entering mitosis. |
|
|
| |
Maenpaa JU, Ala-Fossi SL. Drugs Aging. 11:261-70 (1997). |
|
|
| |
Warri AM, Huovinen RL, Laine AM et al. J Natl Cancer Inst. 85:1412-8 (1993). |
|
|
| |
|
|
|
| T5672 |
Tosufloxacin Tosylate |
100 mg |
$65.60 |
| |
C19H15F3N4O3.C7H8O3S FW 576.55 [115964-29-9] |
500 mg |
$246.00 |
| |
Antimicrobial agent. |
1 g |
$409.90 |
| |
Mori S, Ohashi K, Akiyama H, Kansenshogaku Zasshi. 68:872-8 (1994). |
|
|
| |
|
|
|
| T5677 |
Total Cell Death Assay Kit |
125 Tests |
$362.50 |
| |
|
250 Tests |
$600.90 |
| |
|
|
|
| T6802 |
Tramadol Hydrochloride |
500 mg |
$110.40 |
| |
C16H25NO2.HCl FW 299.84 [22204-88-2] |
1 g |
$172.50 |
| |
An analgesic, acts by inhibiting type 3 muocarinic receptors function via |
5 g |
$703.80 |
| |
quinuclidinyl benzilate binding sites. It activates the mu and kappa opioid receptors. |
|
|
| |
Shiga Y, Minami K, Shiraishi M et al. Anesth Analg. 95:1269-73 (2002). |
|
|
| |
Sun HL, Zheng JW, Wang K et al. Life Sci. 72:1221-30 (2003). |
|
|
| |
|
|
|
| T6803 |
Trandolapril |
100 mg |
$175.00 |
| |
C24H34N2O5 FW 430.54 [87679-37-6] |
250 mg |
$340.00 |
| |
Is an ACE inhibitor used to treat high blood pressure, it may also be used to treat |
500 mg |
$580.00 |
| |
other conditions. |
|
|
| |
Nakou, E. Expert Opinion on Pharmacotherapy (2008), 9(10), 1629-1639. |
|
|
| |
|
|
|
| T6811 |
Tranexamic acid |
5 g |
$18.80 |
| |
C8H15NO2 FW 157.21 [1197-18-8] |
10 g |
$31.40 |
| |
An antifibrinolytic agent. Inhibits plasmin-induced fibrinolysis by |
50 g |
$100.40 |
| |
binding plasmin. |
|
|
| |
Iwamoto M. Thrombosis et Diathesis Haemorrhagica. 33:573-585 (1975). |
|
|
| |
Wellington K, Wagstaff AJ. Drugs. 63:1417-1433 (2003). |
|
|
| |
|
|
|
| T6902 |
Tranilast |
50 mg |
$62.90 |
| |
C18H17NO5 FW 327.34 [53902-12-8] |
100 mg |
$116.50 |
| |
Anti-allergic agent with antiasthmatic property. It was found to have |
500 mg |
$447.60 |
| |
antiangiogenic and antitumor activity. |
|
|
| |
Garcia Mesa M. Allergol Immunopathol (Madr). 18:53-6 (1990). |
|
|
| |
Yatsunami J, Aoki S, Fukuno Y. Int J Oncol. 17:1151-6 (2000). |
|
|
| |
Isaji M, Miyata H, Ajisawa Y et al. Br J Pharmacol. 122:1061-6 (1997). |
|
|
| |
|
|
|
| T6903 |
Tranylcypromine Hydrochloride |
250 mg |
$46.50 |
| |
trans-2-phenylcyclopropylamine hydrochloride |
1 g |
$127.30 |
| |
C9H11N.HCl FW 169.7 [95-62-5] |
|
|
| |
A monoamine oxidase (MAO) inhibitor. It reduces MAO catalyzed conversion of |
|
|
| |
N-acetyl-1,6-diaminohexane(NAD-AH) to 6-acetamidohexanoic acid (AcHA), |
|
|
| |
enhances cell differentiation induced by hexmethylene bisacetamide (HMBA) and its |
|
|
| |
metabolite NAD-AH. |
|
|
| |
Snyder SW, Egorin MJ, Zuhowski EG et al. Cancer Commun. 2:231-6 (1990). |
|
|
| |
|
|
|
| |
Tretinoin (See all trans-retinoic acid) |
|
|
| |
|
|
|
| T6834 |
Triacsin C |
1 mg |
$504.00 |
| |
C11H17N3O FW 207.27 [76896-80-5] |
5 mg |
$2,016.00 |
| |
A long-chain fatty acid acyl-CoA synthetase inhibitor demostrating vasodilating |
|
|
| |
activities. |
|
|
| |
Madusa et. al. J Lipid Res. 47: 87-98 (2006). |
|
|
| |
Hartman EJ, Omura S, Laposata M. Prostaglandins. 37: 655-71 (1989) |
|
|
| |
|
|
|
| T6830 |
Triadimefon |
5 g |
$38.10 |
| |
C14H16ClN3O2 FW 293.75 [43121-43-3] |
10 g |
$60.80 |
| |
Bayleton, a widely used fungicide. P450 inhibitor, induces brassinosteroid |
25 g |
$129.10 |
| |
deficiency in plants. |
|
|
| |
Asami T, Mizutani M, Shimada Y et al. Biochem J. 369:71-76 (2003). |
|
|
| |
|
|
|
| T6831 |
Triadimenol |
10 g |
$45.60 |
| |
C14H18ClN3O2 FW 295.76 [55219-65-3] |
25 g |
$94.10 |
| |
Triazole-type fungicide. Identified as weak estrogen receptor agonists. |
100 g |
$300.60 |
| |
Vinggaard AM, Breinholt V, Larsen JC. Food Addit Contam. 16:533-542 (1999). |
|
|
| |
|
|
|
| T7032 |
Triamcinolone |
50 mg |
$18.00 |
| |
C21H27FO6 FW 394.43 [124-94-7] |
250 mg |
$52.50 |
| |
Glucocorticoid capable of sustaining neuromuscular transmission during |
1 g |
$138.00 |
| |
early motor nerve degeneration. Triamcinolone is also known to induce |
5 g |
$482.90 |
| |
apoptosis in T lymphocytes. |
|
|
| |
Hall ED, Riker WF, Baker T. Exp Neurol. 79:488-96 (1983). |
|
|
| |
Perrin-Wolff M, Bertoglio J, Bressac B et al. Biochem Pharmacol. 50:103-10 (1995). |
|
|
| |
|
|
|
| T6832 |
Triamcinolone acetonide |
50 mg |
$19.70 |
| |
C24H31FO6 FW 434.50 [76-25-5] |
250 mg |
$52.60 |
| |
An antiinflammatory steroid inhibits the IgE-dependent release of histamine |
1 g |
$139.40 |
| |
by human basophils and the growth of NEL-M1 human melanoma cells. |
5 g |
$491.80 |
| |
Schleimer RP, MacGlashan DW Jr et al. J Immunol. 129:1632-6 (1982). |
|
|
| |
DiSorbo DM. Cancer Res. 46:3964-8 (1986). |
|
|
| |
|
|
|
| T7044 |
Triamcinolone Acetonide Acetate |
50 mg |
$18.00 |
| |
C26H33FO7 FW 476.53 |
250 mg |
$48.40 |
| |
A corticosteroid that induces chondrocyte apoptosis in an experimental arthritis |
1 g |
$131.20 |
| |
model. |
5 g |
$476.10 |
| |
Nakazawa F, Matsuno H, Yudoh K et al. Clin Exp Rheumatol. 20:773-81 (2002). |
|
|
| |
|
|
|
| T6933 |
Trichostatin A |
1 mg |
$194.70 |
| |
C17H22N2O3 FW 302.37 [58880-19-6] |
5 mg |
$856.00 |
| |
A histone deacetylase inhibitor. It induces apoptotic cell death in cancer cells. |
|
|
| |
It induces pro-apoptotic genes like ID1, ID2, ID3, down regulates the anti-apoptotic genes, |
|
|
| |
Hsp 27 and Bcl-xL and induces activities of calcium/ calmodulin dependent kinase II and |
|
|
| |
protein kinase C, which have been assigned pro-apoptotic function. |
|
|
| |
Suzuki T, Yokozaki H, Kuniyasu H et al. Int J cancer. 88:992-7 (2000). |
|
|
| |
Eickhoff B, Germeroth L, Stahl C et al. J Biol Chem. 381:1127-32 (2000). |
|
|
| |
|
|
|
| T6932 |
Triflumizole |
5 g |
$39.20 |
| |
C15H15ClF3N3O FW 345.75 [68694-11-1] |
10 g |
$50.40 |
| |
A pesticide suspected by the EPA to be a cancer causing agent. |
100 g |
$296.80 |
| |
De Resende, G. Ciencia e Agrotecnologia (1996), 20(2), 168-172. |
|
|
| |
|
|
|
| T7031 |
Triflumuron |
10 g |
$25.10 |
| |
C15H10ClF3N2O3 FW 358.70 [64628-44-0] |
25 g |
$43.90 |
| |
A chitin biosynthesis inhibitor. It has been shown to inhibit uridine |
100 g |
$138.00 |
| |
incorporation into RNA. |
|
|
| |
Klitschka GE, Mayer RT, Droleskey RE et al. Toxicol. 39: 307-315 (1986). |
|
|
| |
|
|
|
| T7033 |
Trifluoperazine |
5 g |
$48.40 |
| |
C21H24F3N3S FW 407.50 [117-89-5] |
10 g |
$77.60 |
| |
A phenothiazine class calmodulin antagonist which is known for its inhibition |
25 g |
$146.30 |
| |
of DNA synthesis and cell proliferation activities. It is shown to stimulate Egr-1 |
|
|
| |
gene experession by modulating Ras/MEK/ERK and activation of the E1K-1 pathway |
|
|
| |
in human fibrosarcoma HT1080 cells. Trifluoperazine also induces apoptosis in human |
|
|
| |
cholangiocarcinoma cells in vitro, probably acting via the Fas system. |
|
|
| |
Shin SY, Kim SY, Kim JH et al. J Biol Chem. (2000). |
|
|
| |
Pan G, Vickers SM, Pickens A et al. Am J Pathol. 155:193-203 (1999). |
|
|
| |
|
|
|
| T6934 |
Trimebutine maleate |
1 g |
$30.90 |
| |
C22H29NO5.C4H4O4 FW 503.54 [34140-59-5] |
5 g |
$52.80 |
| |
Gastrointestinal antispasmotic. |
|
|
| |
Yamada K, Iizuka M, Takaiti O. Jpn J Pharmacol. 33:301-8 (1983). |
|
|
| |
|
|
|
| T6935 |
Trimebutine base |
10 g |
$62.70 |
| |
C22H29NO5 FW 387.47 [39133-31-8] |
50 g |
$175.60 |
| |
An opioid receptor agonist. |
|
|
| |
Luttecke K. J Int Med Res. 6:86-88 (1978). |
|
|
| |
Kountouras J, Chatzopoulos D, Zavos C et al. Hepato-Gastroenterology. 49:193-197 (2002). |
|
|
| |
|
|
|
| T7133 |
Trimetazidine |
250 mg |
$42.60 |
| |
C14H22N2O3 FW 266.34 |
1 g |
$67.20 |
| |
A vasodilator shown to exert a marked anti-ischemic effect on patients with left |
5 g |
$252.00 |
| |
ventricle dysfunction and moderate heart failure. |
|
|
| |
Tepliakov et. al. Klin Med (Mosk). 82: 57-62 (2004). |
|
|
| |
|
|
|
| |
|
|
|
| T7034 |
Trimethoprim |
5 g |
$38.10 |
| |
C14H18N4O3 FW 290.32 [738-70-5] |
25 g |
$151.90 |
| |
Antimicrobial agent. Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used |
100 g |
$425.00 |
| |
to treat urinary and respiratory tract infections and for prophylaxis and treatment of |
|
|
| |
P carinii infection. TMP-SMX combination may be used for patients with beta-lactam intolerance. |
|
|
| |
Cunha BA. Postgrad Med. 101:68-70 (1997). |
|
|
| |
Safdar A, Armstrong D. Clin Microbiol. 41:483-485 (2003). |
|
|
| |
|
|
|
| T7035 |
Triptolide |
1 mg |
$82.90 |
| |
C20H24O6 FW 360.40 [38748-32-2] |
5 mg |
$345.00 |
| |
A diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium |
|
|
| |
wilfordi. It has inhibitory activity on breast, stomach, and leukemia HL-60 cells. Triptolide induces |
|
|
| |
apoptosis in tumor cells by blocking NF-KB activation and sensitizing tumor cells for TNF-a induced |
|
|
| |
programmed cell death. |
|
|
| |
Wei YS, Adachi I. Chung Kuo Yao Li Hsueh Pao. 12:406-10 (1991). |
|
|
| |
Chang WT, Kang JJ, Lee KY et al. J Biol Chem. 276:2221-7 (2001). |
|
|
| |
|
|
|
| T7037 |
Triptorelin Acetate |
10 mg |
$117.60 |
| |
C64H82N18O13 FW 1311.46 [57773-63-4] |
25 mg |
$252.00 |
| |
A gonadotropin releasing hormone (GnRH) agonist. |
100 mg |
$784.00 |
| |
Weiss JM, Polack S, Treeck O, Diedrich K, Ortmann O. Endocrine. 30:139-44 (2006). |
|
|
| |
|
|
|
| T7036 |
Triptorelin, [DTrp6]-LH-RH, Amide |
10 mg |
$80.30 |
| |
C64H83N18O13 FW 1311.5 |
25 mg |
$200.70 |
| |
A GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation. |
|
|
| |
Grundker C, Gunthert AR, Hellriegel M et al. Eur J Endocrinol. 151(5):619-628 (2004). |
|
|
| |
|
|
|
| T7135 |
Triticonazole |
5 g |
$39.20 |
| |
C17H20ClN3O FW 317.81 [131983-72-7] |
10 g |
$56.00 |
| |
A pesticide suspected by the EPA of being a carcinogen. |
100 g |
$308.00 |
| |
Boerjesson, E. Journal of Environmental Quality (2003), 32(4), 1258-1261. |
|
|
| |
|
|
|
| T7056 |
Troglitazone |
10 mg |
$53.20 |
| |
C24H27NO5S FW 441.54 [97322-87-7] |
50 mg |
$205.10 |
| |
A novel antidiabetic agent. It is found to exert significant cell cycle arrest and |
100 mg |
$303.60 |
| |
apoptosis in hepatocellular carcinoma cell lines. It has a unique property of |
|
|
| |
selectively inducing EGR-1 gene independent of PPARg. Potential preventive agent for colon carcinogenesis. |
|
|
| |
Fugiwara T, Horikoshi H. Life Sci. 67:2405-16 (2000). |
|
|
| |
Osawa E et al. Gastroenterology. 124:361-367 (2003). |
|
|
| |
Baek SJ, Wilson LC, His LC, Eling TE. J Biol Chem. 278:5845-53 (2003). |
|
|
| |
|
|
|
| T7158 |
Tropicamide |
100 mg |
$34.50 |
| |
C17H20N2O2 FW 284.35 [1508-75-4] |
500 mg |
$89.70 |
| |
A specific muscarinic (M4) antagonist. |
1 g |
$138.00 |
| |
Blessel K W et al. Anal Profiles Drug Subs. 3:565-80 (1974). |
|
|
| |
|
|
|
| T7156 |
Tropisetron Hydrochloride |
10 mg |
$41.40 |
| |
C17H20N2O2.HCl FW 320.82 [105826-92-4] |
50 mg |
$117.40 |
| |
A 5-hydroxytryptamine 3 receptor antagonist. Found to be a potent and selective |
100 mg |
$172.50 |
| |
partial agonist at a7 nicotinic receptors. |
|
|
| |
Tonini M, Candura SM Onori L et al. Life Sci. 50:PL173-8 (1992). |
|
|
| |
|
|
|
| T7197 |
Tryprostatin A |
0.5 mg |
$341.20 |
| |
C22H29N3O3 FW 383.48 |
|
|
| |
An antimitotic agent that interferes with the interaction between tubulin and microtubular |
|
|
| |
association protein. |
|
|
| |
Osada H. Current Med Chem. 10:727-732 (2003). |
|
|
|
|
|
|
| T8004 |
Tubeimoside I |
10 mg |
$45.60 |
| |
C63H98O29 FW 1319.43 [102040-03-9] |
25 mg |
$91.20 |
| |
A triterpenoid saponin isolated from tubers of bolbostemma paniculatum, |
100 mg |
$296.10 |
| |
Franquet, a traditional Chinese medicine "Tu-Bei-Mu". Used as anti-tumor agent, induces cell cycle arrest and apoptosis. |
|
|
| |
Yang P, Yu Tx, Ma RD et al. Ai Zheng. 21:346-350 (2002). |
|
|
| |
|
|
|
| T8020 |
Tuftsin |
5 mg |
$35.80 |
| |
C21H40N8O6 FW 500.60 |
10 mg |
$60.90 |
| |
An endogeneous peptide that is known to have immunogenic activity against |
25 mg |
$107.50 |
| |
tumors and pathogens by potentiating monocytes, macrophages, and polymorphonuclear leukocytes. |
|
|
| |
Gupta CM, Haq W. Methods Enzymol. 391: 291-304 (2005). |
|
|
| |
|
|
|
| T8145 |
Tulobuterol |
1 g |
$56.00 |
| |
A beta-adrenoreceptor agonist used in the treatment of moderate to severe asthma. |
5 g |
$224.00 |
| |
Yoshihara S, Yamada Y, Abe T, Arisaka O. Ann Allergy Asthma Immunol. 96: 879-80-(2006). |
|
|
| |
Nishiyama et. al. Clin Exp Pharmacol Physiol. 33:1016-21 (2006). |
|
|
| |
|
|
|
| T8153 |
Tunicamycin |
1 mg |
$33.20 |
| |
C40H66N4O16 Avg. FW 840.0 [11089-65-9] |
5 mg |
$110.30 |
| |
A glucosamine-containing pryrimidine nucleotide and an inhibitor of |
10 mg |
$184.40 |
| |
glucosaminyl-1-phosphate transferase. It induces apoptosis in cultured brain neurons, |
|
|
| |
Melanoma and SV40- transformed cells by inhibiting N-linked glycosylation. |
|
|
| |
Lin TY, Wang SM, Fu WM, Chen YH, Yin HS. J Cell Biochem. 74:638-47 (1999). |
|
|
| |
Dricu A, Carlberg M, Wang M, Larsson O. Cancer Res. 57:543-8 (1997). |
|
|
| |
|
|
|
| T9945 |
Tylosin tartrate |
1 g |
$19.40 |
| |
C46H77NO17.C4H4O6 FW 1066.2 [1405-54-5] |
5 g |
$55.20 |
| |
A macrolide antibiotic used in animal feed. |
10 g |
$96.70 |
| |
Knothe H. Infection. 5:183-7 (1977). |
|
|
| |
|
|
|
| T9946 |
Tylosin phosphate |
1 g |
$19.40 |
| |
C46H77NO17.H3PO4 FW 1014.11 [1405-53-4] |
5 g |
$55.20 |
| |
|
10 g |
$96.70 |
| |
|
|
|
| T9974 |
[Asp371] Tyrosinase (369-377), human |
1 mg |
$100.40 |
| |
C42H66N10O16S2 FW 1031.2 |
|
|
| |
|
|
|
| T9968 |
Tyrphostin A25 |
5 mg |
$45.90 |
| |
C10H6N2O3 FW 202.17 [118409-58-8] |
25 mg |
$157.50 |
| |
Protein tyrosine kinase inhibitor. |
|
|
| |
Gazit, A. et al. J Med Chem. 32:2344-52 (1989). |
|
|
| |
|
|
|
| T9969 |
Tyrphostin AG490 |
5 mg |
$57.80 |
| |
C17H14N2O3 FW 294.30 [34036-52-5] |
10 mg |
$98.80 |
| |
A selectrive PDGF receptor autophosphorylation inhibitor. |
25 mg |
$220.20 |
| |
Kovalenko M et al. Cancer Res. 54:6106-6114 (1994). |
|
|
| |
Levitsky A, Gazit A. Science. 267:1782-1788 (1995). |
|
|
| |
|
|
|
| T9970 |
Tyrphostin AG1295 |
1 mg |
$38.10 |
| |
C16H14N2 FW 234.30 [71897-07-9] |
5 mg |
$98.80 |
| |
A specific and potent JAK-2 protein tyrosine kinase inhibitor. Found also to inhibit |
|
|
| |
EGF receptor autophosphorylation and induce apoptosis. |
|
|
| |
Levitzki A. Biochem. Pharmacol. 40:913-918 (1990). |
|
|
| |
Gazit A et al. J Med Chem. 34:1896-1907 (1991). |
|
|
| |
De Vos J et al. Br J Haematol. 109:823-828 (2000). |
|
|
| |
|
|
|