| U0618 |
Ubenimex |
|
|
|
Bestatin
Ubenimex is an antitumor agent effective against murine syngeneic tumors
including mouse colon 26 and C1498 leukemia. It was found to be active
against MNNG-induced rat tumor by oral administration. It also inhibits
leucine aminopeptidase and aminopeptidase B in cell membrane, in addition to
modulating PKC in K562 cells and inducing apoptosis.
Sekine K, Fujii H, Abe F. Leukemia. 13:729-34 (1999).
Tsukagoshi S. Gan To Kagaku Ryoho. 14:2385-91 (1987).
Ebihara K, Abe F, Yamashita
T et al. J Antibiot. 39:966-70 (1986). |
10 mg
50 mg
100 mg |
$43.20
$178.70
$277.20 |
| U5233 |
Universal TT epitope P2 (830-844) |
|
|
|
Addition of this peptide to vaccines enhances the
efficacy of the immune response to malaria prophylaxis.
Fryauff DJ, Mouzin E and Church LW. et. al.Vaccine. 17: 59-63 (1999). |
1 mg
2 mg
5 mg |
$64.00
$108.80
$192.00 |
| U6118 |
Uperolein |
|
|
|
A physalaemin-like endecapeptide that is selective
for Neurokinin 1 receptor.
Dike A, Cowsik SM. J Struct Biol. 156: 442-52 (2006). |
1 mg
2 mg
5 mg |
$70.40
$120.00
$211.20 |
| U6901 |
Uracil |
|
|
|
Used in the treatment of metastatic colorectal
cancer and hormone refractory prostate cancer.
Lin JK, Fan FS, Yen CC et al. Jpn J Clin Oncol. 30:510-4 (2000).
Nishimura K, Nomomura N, Ono Y et al. Oncology. 60:49-54 (2001). |
10 g
25 g
100 g |
$15.30
$23.20
$38.50 |
| U6802 |
Urapidil hydrochloride |
|
|
|
|
500 mg
1 g
5 g |
$49.30
$80.10
$308.00 |
| U6854 |
Urocortin, human |
|
|
|
A CRF-related peptide involved in the relaxation of
pulmonary arteries.
Lau CW, Chan YC, Yao X. Eur J Pharmacol. 488:169-172 (2004). |
0.5 mg
1 mg
2.5 mg |
$160.00
$272.00
$480.00
|
| U6855 |
Urocortin, rat |
|
|
|
|
0.5 mg
1 mg
2.5 mg |
$160.00
$272.00
$480.00
|
| U6856 |
Urocortin II, human |
|
|
|
A selective CRF receptor type 2 agonist that
enhances contractility of ventricular mycocytes in rabbit.
Yang LZ, Kockskamper J, Heinzel FR. et. al. Cardiovasc Res. 69: 402-11
(2006). |
0.5 mg
1 mg
2.5 mg |
$224.00
$380.80
$672.00 |
| U6858 |
Urocortin II, mouse |
|
|
|
|
0.5 mg
1 mg
2.5 mg |
$224.00
$380.80
$672.00 |
| U6859 |
Urocortin III, human |
|
|
|
A selective CRF receptor type 2 agonist that
exhibits bronchorelaxant and anti-inflammatory activities.
Moffatt JD, Lever R, Page CP. FASEB J. 20:1877-9 (2006). |
0.5 mg
1 mg
2.5 mg |
$224.00
$380.80
$672.00 |
| U6860 |
Urocortin III, mouse |
|
|
|
|
0.5 mg
1 mg
2.5 mg |
$224.00
$380.80
$672.00 |
| U6857 |
Urodilatin CCC/ANP-95-126 |
|
|
|
A renal natriuretic peptide that has been shown to
possess a vasodilatory effect in pulmonary circulation.
Schermuly RT, Weissman N, Enke B et al. Am J Respir Cell Mol Biol.
25:219-225 (2001). |
1 mg |
$288.00 |
| U6956 |
Uroguanylin, human |
|
|
|
An endogenous ligand that binds and stimulates
intestinal guanylate cyclase-C.
Whitaker TL, Steinbrecher KA, Copeland NG, Gilbert DJ, Jenkins NA, Cohen MB.
Genomics. 45: 348-54 (1997). |
0.5 mg
1 mg
2.5 mg |
$121.60
$206.40
$364.80 |
| U6957 |
Urotensin I |
|
|
|
A neuroprotective that increase the survival rate of
central and peripheral neuronons by activation of cAMP-dependent pathways.
Facci L, Stevens DA, Pangallo M, Franceschini D, Skaper SD, Strijbos PJ.
Neuropharmacology. 45: 623-36 (2003).
Marshall WS, Bern HA. Gen Comp
Endocrinol. 43: 484-91 (1981). |
0.5 mg
1 mg
2.5 mg |
$184.00
$313.60
$553.60 |
| U6958 |
Urotensin II (Frog) |
|
|
|
A neuropeptide that inhibits the active chloride
transport of teleost fish.
Marshall WS, Bern HA. Gen Comp Endocrinol. 43: 484-91 (1981). |
0.5 mg
1 mg
2.5 mg |
$108.80
$185.60
$326.40 |
| U6959 |
Urotensin II, human |
|
|
|
|
0.5 mg
1 mg
2.5 mg |
$108.80
$185.60
$326.40 |
| U6873 |
Ursodeoxycholic acid |
|
|
|
A bile acid with significant chemopreventive
activity in the colon.
Wali RK, Frawley BP, Hartmann S et al. Cancer Res. 55:5257-5264 (1995). |
1 g
5 g |
$34.20
$108.70 |
| U7354 |
Usnic acid |
|
|
|
An antimicrobial, antitumor and enzyme inhibiting
agent. Shown to uncouple oxidative phosphorylation in mouse-liver
mitochondria. Induces necrosis in certain cells.
Abo-Khatwa AN, al-Robai AA, al-Jawhari DA. Natural Toxins. 4:96-102 (1996).
Han D, Matsumaru K, Kettori D, Kaplowiz N. Biochem Pharm. 67:439-451
(2004). |
5 g
25 g |
$30.30
$109.80 |
| V0045 |
Valacyclovir Hydrochloride |
|
|
|
L-valine ester of acyclovir that increases oral
absorption before conversion to acyclovir.
Ormrod D, Scott LJ, Perry CM. Drugs. 59:839-63 (2000). |
50 mg
100 mg
500 mg |
$58.30
$100.00
$407.50 |
| V0145 |
Valinomycin |
|
|
| 2-8 oC |
A potassium ionophore that is well known to cause
the collapse of the mitochondrial membrane potential, which precedes
cytoplasmic acidification, cysteine-active-site protease activation, DNA
fragmentation and apoptotic cell death.
Inai Y, Yabuki M, Kanno T et. al. Cell Struct Funct. 22:555-63 (1997).
Furlong IJ, Lopez Mediavilla C, Ascaso R et al. Cell Death Differ. 5:214-21
(1998). |
5 mg
10 mg
25 mg |
$30.80
$53.90
$97.70 |
| V0252 |
Vancomycin Hydrochloride |
|
|
|
A glycopeptide antibiotic that is commonly used for
treatment of methicillin resistant bacteria. It has been shown to inhibit
glucose 6-phosphate dehydrogenase in vitro.
Beydemir S, Kulacoglu DN, Ciftci M, Kfrevioglu OI. Eur J Ophthal.
13:155-161 (2004).
Homer P, Peyman GA, Koziol J, Sanders D. Acta Ophthal. 53:311-320 (1975). |
100 mg
250 mg
1 g |
$22.40
$42.60
$134.40 |
| V0153 |
Vanilloid Receptor Subtype 1 (VR1) |
|
|
|
A heat-gated ion channel that mediates responses fo
sensory neurons.
Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. Nature 398: 436-41
(1999). |
1 mg
2 mg
5 mg |
$102.40
$174.40
$307.20 |
| V0160 |
RC-160 (Vapreotide) |
|
|
|
C57H70N12O9S2
Mol Wt: 1131.4
[103222-11-3]
An octapeptide derivative of somatostatin (SRIF) capable of inhbiting growth
in OV-1063 human epithelial cancer cells.
Yano T, Radulovic S, Osuga Y et al. Oncology. 59 suppl 1:45-49 (2000). |
0.5 mg
1 mg
2.5 mg |
$70.40
$120.00
$211.20 |
| V0273 |
Vasoactive Intestinal peptide (VIP) |
|
|
|
A neuropeptide that exhibits anti-inflamatory
properties by inducing regulatory dendritic cells.
Gonzalez-Rey E, Delgado M. Gastroenterology. 131: 199-811 (2006). |
0.5 mg
1 mg
2.5 mg |
$83.20
$140.80
$249.60 |
| V3360 |
VIP, guinea pig |
|
|
|
Vasoactive Intestinal peptide, guinea pig |
0.5 mg
1 mg
2.5 mg |
$108.80
$185.60
$326.40 |
| V0274 |
[Lys8] Vasopressin |
|
|
|
A neurohypophyseal peptide that mediates central and
peripheral antidiuretic effects as a result of modifying four different G
protein receptors.
Pena A, Murat B, Trueba M et. al. J Med Chem. 50: 835-47 (2007). |
1 mg
2 mg
5 mg |
$32.00
$54.40
$96.00 |
| V0275 |
[Arg8] Vasotocin |
|
|
|
A neuropeptide hormone that controls water and salt
metabolism.
Leake RD, Weitzman RE. Clin Perinatol. 6: 65-85 (1979). |
1 mg
2 mg
5 mg |
$32.00
$54.40
$96.00 |
| V1810 |
Vecuronium Bromide |
|
|
|
A nonpolarizing neuromuscular relaxant.
Marshall IG, Agoston S, Booij LH et al. Br J Anaesth. 52 Suppl 1:11S-19S
(1980). |
10 mg
50 mg
100 mg |
$55.50
$154.00
$246.40 |
| V1854 |
Venlafaxine Hydrochloride |
|
|
|
A heterocyclic antidepressant inhibits the re-uptake
of serotonin, norepinephrine, and dopamine.
Morton WA, Sonne SC, Verga MA. Ann Pharmacother. 29:387-95 (1995). |
500 mg
1 g
5 g |
$39.50
$64.10
$264.90 |
| V1769 |
(±)Verapamil Hydrochloride |
|
|
|
A calcium channel blocker with chemopreventive
character. Verapamil was found to inhibit carcinogen-induced aberrant crypt
foci formation, mammary carcinogenesis, and pancreatic carcinogenesis.
Wargovich MJ, Jimenez A, Mckee K et al. Carcinogenesis.
21:1149-55 (2000).
Soybir G, Koksoy F, Koyuncu H et al. Breast Cancer Res Treat. 50:193-9
(1998).
Nakaizumi A, Uehara H, Baba M et al. Cancer Lett. 105:23-7 9 (1996). |
1 g
5 g |
$36.90
$110.70 |
| V1870 |
Verruculogen |
|
|
|
C27H33N3O7
Mol.Wt.: 511.567
[12771-72-1]
A tremorgenic neurochemical produced by various soil fungi.
Paterson D, Shreeve B, Robberts B, MacDonald S, Appl Environ Microbiol. 42:
916-7 (1981).
Norris P, Smith C, De Belleroche J, Bradford H, Mantle P,
Thomas A, Penny R. J Neurochem. 34: 33-42 (1980). |
1 mg
5 mg |
$72.00
$298.00 |
| V1872 |
Vesicular Stomatitis Virus peptide |
|
|
|
A antigenic peptide of vesicular stomatitis virus
binds to H-2Kb antigens.
Shibata K, Imarai M, van Bleek GM et. al. Proc Natl Acad Sci U S A. 89:
3135-9 (1992). |
1 mg
2 mg
5 mg |
$32.00
$59.20
$105.60 |
| V3212 |
Vidarabine |
|
|
|
Anti-leukemic agent.
Honma Y, Nitsu N. Leuk Lymphoma. 399:57-66 (2000). |
100 mg
500 mg
1 g |
$30.80
$86.20
$138.40 |
| V3253 |
Vinblastine sulfate |
|
|
|
A vinca alkaloid isolated from Vinca rosea
(periwinkle). It is an antimitotic agent which binds to tubulin. Clinically
used as an antitumor agent.
Gorman M et al. J Amer Chem Soc. 81:4745 (1959).
Mareel MM, De Brabander MJ. J Natl Cancer Inst.
61:787-92 (1978). |
5 mg
10 mg |
$70.70
$128.00 |
| V5254 |
Vincristine sulfate |
|
|
|
An antimitotic agent which binds to tubulin.
Clinically used as an antitumor agent. Induces apoptosis.
Mareel MM, Storme GA, De Bruyne GK, Van Cauwenberge RM. Eur J Cancer Clin
Oncol. 18:199-210 (1982).
Harmon BV, Takano YS, Winterford CM, Potten
CS. Cell Prolif. 25:523-36 (1992). |
5 mg
10 mg |
$122.40
$220.40 |
| V3354 |
Vindesine sulfate |
|
|
|
Vindesine, a vinca alkaloid derived from
vinblastine. Potentially useful against a variety of solid and hematological
malignancies. More often used in combination regimens with cisplatin and
ifosfamide.
Dancey J, Steward WP. Anticancer Drugs. 6:625-636
(1995).
Kodani T, Ueoka H, Kiura K et al. Lung Cancer. 36:313-319 (2002). |
1 mg
5 mg
10 mg |
$70.50
$271.10
$474.40 |
| V3355 |
Vindoline |
|
|
|
Monomeric vinca-alkaloid, forms lower portion of the
lead anti-tumor agents, vinblastine and vincristine. Found to exhibit
reciprocal cross-resistance to vincristine and vinblastine.
Fahy J. Curr Pharm Des. 7:1181-1197 (2001).
Inaba M, Nagashima
K. Jpn J Cancer Res. 77:197-204 (1986). |
25 mg
100 mg
500 mg |
$51.60
$132.90
$508.30 |
| V3251 |
Vinorelbine base |
|
|
|
Member of vinca-alkaloid. It is used in the
treatment of anthracycline-resistent advanced breast cancer and recommended
for the treatment of bronchial cancer.
Brown RE, Hutton J, Burrell A. Pharmacoeconomics. 19:1091-1102 (2001).
Ribet JP, Zalavari
P, Commenges G et al. Ann Pharm Fr. 55:20-34 (1997). |
1 mg
5 mg
25 mg |
$47.50
$169.50
$657.40 |
| V3252 |
Vinorelbine Ditartrate |
|
|
|
A chemotherapeutic agent effective against a number
of solid tumors including non-small-cell carcinoma, advanced prostatic
carcinoma, breast cancer, head and neck cancer, and Hodgkin's lymphoma. It
induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma
cells.
Goa KL, Faulds D. Drugs Aging. 5:200-34 (1994).
Jones SF, Burris HA 3rd. Ann Pharmacother. 30:501-6 (1996).
Toh HC, Sun L, Koh CH, Aw SE. Leuk Lymphoma. 31:195-208 (1998). |
1 mg
5 mg
25 mg |
$61.10
$196.60
$792.90 |
|
Vitamin A |
|
|
|
See Retinol |
|
|
|
Vitamin B6 |
|
|
|
See Pyridoxine HCl |
|
|
| V3378 |
Vitamin B12 |
|
|
|
Also known as methylcobalamin/cobalamine. Prevents
chronic diseases, including cancer, coronary heart disease, and
osteoporosis.
Fairfield KM, Fletcher RH. JAMA. 287:3116-31126 (2002).
Ames BN, Wakimoto P. Nat Rev Cancer. 2:694-704 (2002). |
500 mg
1 g
5 g |
$40.70
$67.80
$223.70 |
| V3476 |
Vitamin D2 |
|
|
|
One of the vitamin D family. It is used in the
treatment of refractory rickets (vitamin D resistant rickets), familial
hypophosphatemia and hypoparathyroidism. It also has a strong inhibitory
effect against bladder tumor promotion by sodium saccharin and induces cell
differentiation in leukemia cells.
Yazawa Y, Yokota M, Sugiyama K, Biol Pharm Bull. 23:1298-302 (2000).
Yen A, Blue J, Forbes M. In vitro cell dev Biol. 27A:518-20 (1991). |
1 g
5 g |
$69.30
$271.30 |
|
Vitamin D3 |
|
|
|
See Cholecalciferol |
|
|
| V3277 |
Vitamin E |
|
|
|
D,L-a-Tocopherol
An antioxidant and anticarcinogen toward a variety of cancers.
Wattenberg LW. Cancer Res. 45:1-8 (1985). |
100 g
500 g |
$44.30
$169.80 |
| V3479 |
Vitamin K3 |
|
|
|
2-Methyl-1,4-naphthoquinone, menadione
Induces apoptosis in various cultured cells including leukemia cells. It has
been shown that vitamin K exerts anti-tumor activity by inhibiting cdk1
activity and over expressing the c-myc gene to induce apoptotic cell death.
Another hypothesis based on investigation done on the mode of actions of
vitamin K suggests that VK3 induces apoptosis by promoting the generation of
intracellular reactive oxygen intermediates and Fas/APO-1 expression.
Nishimaki J,
Miyazawak, Yaguchi M et al. Leukemia. 13:1399-405 (1999).
Wu FY, Sun TP. Eur J Cancer. 35:1388-93 (1999).
Sun LK, Yoshii Y, Miyagi K. J Neurooncol. 47:31-8 (2000). |
10 g
25 g |
$15.30
$24.60 |
| W4096 |
W-K-Y-M-V-M-NH2 |
|
|
|
A formyl peptide receptor-like 1 ligand, induces
superoxide production by human neutrophils.
Lee HY, Jo SH, Lee C, Baek SH, Bae YS. Biochem Pharmacol. 72: 860-8 (2006). |
0.5 mg
1 mg
2.5 mg |
$44.80
$75.20
$134.40 |
| W5726 |
Wogonin |
|
|
|
5,7-Dihydroxy-8-methoxyflavone
C16H12O5
Mol. Wt. 248.26
[632-85-9]
A flavanoid compound that exhibits cell apoptotic and cytotoxic effects in
Bel-7402 cells.
This compound also demostrates anti-inflammatory and anti-cancer activities.
Yu JQ, Liu HB, Tian DZ, Liu YW, Lei JC, Zou GL. Hepatol Res. 37: 68-76
(2007).
Tai MC, Tsang SY, Chang LY, Xue H. CNS Drug Rev. 11:141-50 (2005). |
5 mg
10 mg
25 mg |
$65.00
$98.00
$220.00 |
| W5769 |
Wortmannin |
|
|
|
An inhibitor of PI3-K and DNA-dependent protein
kinase, which is known to mediate DNA double strand break repair. It induces apoptosis and also sensitizes cells to ionizing radiation.
Boulton S, Kyle S, Yalcintepe L, Durkacz BW. Carcinogenesis.
17: 2285 -90 (1996).
Ng SSW, Tsao MS, Chow S, Hedley DW. Cancer Res. 60: 5451-5 (2000).
Kubota N, Okada S, Inada T, Ohnishi K, Ohnishi T. Cancer Lett. 161:141-7
(2000). |
1 mg
5 mg |
$52.90
$208.60 |
| X1752 |
Xenin |
|
|
|
An amphibian xenopsin-related peptide that
stimulates exocrine pancreatic secretion.
Feurle GE, Hamscher G, Kusiek R, Meyer HE, Metzger JW. J Biol Chem. 267:
22305-9 (1991).
Hamscher G, Meyer HE, Metzger JW, Feurle GE. Peptides. 16: 791-7 (1995). |
0.5 mg
1 mg
2.5 mg |
$121.60
$206.40
$364.80 |
| X1753 |
Xenopsin |
|
|
|
|
1 mg
2 mg
5 mg |
$32.00
$54.40
$96.00 |
| X1854 |
p-Xyleneselenocyanate, 99% |
|
|
|
A synthetic organoselenium chemopreventive agent.
Found to inhibit chemically induced carcinogenesis in the mammary glands, colon and lung of laboratory animals.
Tanaka T, Makita H, Kawabata K et al. Cancer Res. 57:3644-3648 (1997).
Prokopczyk B, Amin S, Desai DH et al. Carcinogenesis. 9:1855-1857 (1997). |
100 mg
250 mg
500 mg |
$50.00
$100.00
$173.80 |
| Y0052 |
Yangonin |
|
|
|
One of the major components of kava extract reported
to have binding affinities to CNS receptors.
Dinh LD, Simmen U, Bueter KB. Planta Med. 67:306-11 (2001). |
5 mg
10 mg |
$99.50
$153.70 |
| Z0146 |
Z-Ala-Ala-Leu-pNA |
|
|
|
C26H33N5O7
Mol Wt: 527.6
[61043-33-2] |
100 mg
250 mg |
$80.00
$160.00 |
|
Zalcitabine |
|
|
|
See 2',3'-Dideoxycytidine
An anti-HTLV-III/LAV drug. |
|
|
| Z1216 |
Z-D-E-V-D-AMC |
|
|
|
Ac-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin
A fluorogenic peptide substrate used to determine caspase activties.
Haviv R, Lindenboim L, Li H, Yuan J, Stein R. J Neurosci Res. 50: 69-80
(1997). |
5 mg
10 mg
25 mg |
$185.60
$315.20
$556.80 |
| Z2268 |
Z-F-R-AMC |
|
|
|
A peptide substrate used to experimentally determine
cathepsin B and L activities.
Li Y. et. al. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 16:
101-4 (1998). |
10 mg
20 mg
50 mg |
$147.20
$249.60
$441.60 |
| Z6269 |
Z-Pro-D-Leu |
|
|
|
A synthetic peptide derived from the c-terminus
fragment of oxytocin. It is an effective inhibitor of tolerance to and dependence on morphine in mice.
Kovacs GL, Acsai L, Tihanyi A, Faludi M, Telegdy G. Pharmacol Biochem Behav.
18: 345-9 (1983). |
10 mg
20 mg
50 mg |
$64.00
$108.80
$192.00 |
| Z1602 |
Zearalenone |
|
|
|
An estrogenic mycotoxin produced by genus Fusarium
found in cerea grains. Zearalenone induced apoptosis and proliferation in granusola cells from cycling mare ovaries.
Tiemann U, Danicke S. Food Addit Contam. 24: 306-14 (2007).
Minervini
F, Giannoccaro A, Fornelli F. et. al. Reprod Biol Endocrinol. 4: 62 (2006). |
1 mg
5 mg
10 mg |
$20.00
$40.00
$72.00 |
|
Zidovudine |
|
|
|
See 3'-Azido-3'-deoxythymidine (AZT) |
|
|
| Z5744 |
Zoledronic acid |
|
|
|
A potent bone resorption inhibitor. May improve
osteosarcoma treatments when administered with anticancer agents.
Schortinghuis J, Witjes MJ, Spijkervet KL, de Visscher JG. Ned Tijdschr
Geneeskd. 151:314-8 (2007).
Horie N et. al.Br J Cancer. 96: 255-61
(2007). |
10 mg
25 mg
100 mg |
$50.00
$100.00
$300.00 |
| Z5653 |
Zonisamide |
|
|
|
A new-generation antiepileptic drug (AED) with
applications as an antinocireceptive agent.
Sakaue A, Honda M, Tanabe M, Ono H. J Pharm Sci. 95:181-8 (2004). |
10 mg
25 mg
100 mg |
$89.60
$168.00
$560.00 |
