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Description
The most active paullone. It is a potent inhibitor of glycogen synthase kinase-3b and cyclin - dependent kinase 5/p25. It has been shown to induce apoptosis and promote loss in clonogenicity in the Jurkate cell line.
Leost M, Schultz C, Link A et al. European J Biochem. 267:5983-94 (2000).
Lahusen T, De Siervi A, Kunick C et al. Molecular Carcinogenesis. 36:183-94 (2003).