Beauvericin

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Beauvericin, a cyclic hexadepsipeptide with alternating L-N-methylphenylalanyl and D-a-hydroxyisovaleryl residues, is a mycotoxin derived from the mould Beauveria bassiana, Fusarium strains and other moulds. Beauvericin shows cytotoxic, Immunosuppressant, and apoptotic activity. It is the most potent specific inhibitor of cholesterol acyltransferase and possesses ionophoric properties. It increases ion permeability in biological membranes by forming a complex with essential cations (Ca2+, Na+, K+), which may affect the ionic homeostasis.