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Description
An isoqinoline alkaloid found in plants of the genera Berberis and Coptis. It was shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. It also inhibites Activator Protein 1 (AP-1), a transcription factor which palys a critical role in inflammation and carcinogenesis.
Soluble in boiling water. Slightly soluble in cold water.
Stability
Protect from light.
Store Temp
Ambient
References
Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao s., Fujiwara H. J. Ethno. 66:227-33 (1999).
Fukuda K., Hibiya Y., Mutah M., Koshiji M., Akao s., Fujiwara H. Planta Med. 65:381-3 (1999).