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PRODUCT
Geldanamycin |
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Description
A benzoquinoid ansamycin antibiotic having antitumor activities. It suppresses
DNA replication by inhibiting c-myc gene expression in lymphoblastoma L5178Y cells.
It inhibits tyrosine kinases and induces increased p53 protein involved in cell-cycle arrests
of human ovarian tumor cells. It inhibits the 90 kDa heat shock protein that reglates
cell signal transduction, and telomerase activity, and induces apoptosis.
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