Irinotecan HCl trihydrate

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Product No	Price	Quantity	Subtotal
I6933-5mg	$45.00
I6933-10mg	$65.00
I6933-25mg	$100.00
I6933-100mg	$168.00
	Total

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Description

Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

Specifications

Cas No.	136572-09-3
Product ID	I6933
Product Name	Irinotecan HCl trihydrate
Chemical Name	[1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
Synonym	Irinotecan hydrochloride trihydrate; Camptosar; Campto
Formula Wt.	677.19
Melting Point	256.5^oC
Purity	≥98%
Solubility	Slightly soluble in water, ethanol, chloroform.
Store Temp	Ambient
References	Kellner U, Rudolph P, Parwaresch R. Onkologie. 23:424-430 (2000). Kalemkerian GP, Worden FP. Expert Opin Investing Drugs. 9:565-79 (2000). Saltz LB. Curr Oncol Rep. 1:155-160 (1999).