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Description
Leptomycin B (LepB) is an antifungal antibiotic, found to be a potent antitumor agent. It is suggested that the antitumor effect is related to cytochrome c release, activation of caspases, and selective down-regulation ofMc1-1 and XIAP. Leptomycin B has
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| Cas No. |
87081-35-4 |
| Product ID |
L1761 |
| Product Name |
Leptomycin B |
| Chemical Name |
19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- 2,10,12,16,18-Nonadecapentaenoic acid |
| Synonym |
LMB; Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720. |
| Formula Wt. |
540.74 |
| Melting Point |
41oC-44oC |
| Purity |
≥98%
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| Solubility |
Soluble in ethanol or methanol. |
| Stability |
WARNING: Small quantities of LepB are reported to be unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of LepB, because rapid decomposition may result. |
| Store Temp |
-20oC |
| References |
Sasaki H, Yoshida M, Beppu T. Radiat Res. 129:163-70 (1992).
Jang BC, Paik JH, Jeong HY et al. Biochem Pharmacol. 68:263-74 (2004).
Meissner T, Krause E, Vinkemeier U. FEBS Lett. 576:27-30 (2004).Fukuda.M., et al Nature 390:308-311 (1997).
Kudo, N. |
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