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Description
A tetracycline derivative with antimicrobial activity. It was found to inhibit inducible NO synthase expression and augment cyclo- oxygenase (COX)-2 expression and PGE2 production. Used to treat rheumatoid arthritis. It inhibits angiogenesis.
Hygroscopic. Protect from light. Sensitive to surface oxidation.
Store Temp
+4oC
References
Patel RN. Attur MG. Dave MN. et al. J Immunol. 163:3459-67 (1999).
Jackson CG. Williams HJ. Drugs. 56:337-44 (1998).
Gilbertson-Beadling S. Powers EA. Stamp-Cole M. et al Cancer Chemother Pharmacol. 36:418-24 (1995).