Monastrol

Click over image to enlarge

Description

A cell-permeable small molecule inhibitor of the mitotic kinesin Eg5. It arrests cells in mitosis with monoastral spindles.

Specifications

Cas No.	254753-54-3
Product ID	M5752
Product Name	Monastrol
Chemical Name	1,2,3,4-Tetra- hydro-4-(3-Hydroxyphenyl)- 6-methyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
Formula Wt.	292.35
Melting Point	184^oC-186^oC (lit.)
Purity	≥95%
Solubility	Soluble in DMSO (100mg/mL).
Stability	Protect from light.
Store Temp	-20^oC
Ship Temp	Ambient
References	Kapoor TM, Mayer TU, Coughlin ML et al. J Cell Biol. 150:975-88 (2000). Leizerman I, Avunie-Masala R, Elkabets M et al. Cell Mol Life Sci. 61:2060-70 (2004).