Sulindac sulfide

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Description

An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism.

Specifications

Cas No.	32004-67-4
Product ID	S8147
Product Name	Sulindac sulfide
Chemical Name	1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-(p- (methylthio)benzylidene)-
Formula Wt.	340.42
Melting Point	186-188^oC
Solubility	Soluble in DMSO or ethanol.
Store Temp	Ambient
References	Meade, E.A., Smith, W.L., and DeWitt, D.L. J. Biol. Chem. 268(9): 6610-6614 (1993). Piazza, G.A., Rahm, A.L., Krutzsch, M., Sperl, G., Paranka, N.S., Gross, P.H., Brendel, K., Burt, R.W., Alberts, D.S., Pamukcu, R., et. al. Cancer Res. 55(14): 3110-3