Nemorosone is a polycyclic polyprenylated acylphloroglucinol derived from beeswax and bee saliva. Closely related to hyperforin, nemorosone shows activity as an anti-cancer and anti-inflammatory compound.
Nemorosone inhibited growth of xenografts of MIA-PaCA-2 pancreatic cancer cells in mice over a 28-day trial period. Nemorosone showed better activity than standard treatment with gemcitabine in the same model. Additionally, nemorosone does not activate CYP3A4, unlike structurally related molecule hyperforin. Nemorosone, therefore, has a longer half-life and better absorption in biological systems.
Nemorosone is available exclusively from LKT Laboratories, Inc.
Wolf, RJ, Hilger RA, Hoheisel JD, et al. (2013) “In Vivo Activity and Pharmacokinetics of Nemorosone on Pancreatic Cancer Xenografts.” PLoS ONE 8(9): e74555. Doi:10.1371/journal.pone.0074555