Type 2 diabetes is a chronic condition in which the body resists the effects of insulin or doesn’t produce enough insulin to maintain a healthy glucose level. Since insulin is a hormone that regulates the the metabolism of sugar, type 2 diabetes typically leads to high blood sugar, which can lead to heart disease or kidney failure.
Sulforaphane, a natural compound found in broccoli, cauliflower, and other cruciferous vegetables, has been identified as a possible counter to type 2 diabetes. In a study published in June of 2017 by Lund University, R-Sulforaphane from LKT Labs was shown to suppress glucose production from hepatic cells by nuclear translocation of NRF2, and decreased the expression of important enzymes in gluconeogenesis. Sulforaphane also reversed the disease signature in the livers of diabetic animals. Finally, sulforaphane was also administered to obese patients with dysregulated type 2 diabetes, and was shown to reduce fasting blood glucose and glycated hemoglobin.
R,S-Sulforaphane is a synthetic organosulfur compound that displays a variety of interesting characteristics, including anticancer, antimicrobial, antioxidative, anti-inflammatory, and neuroprotective activities. It is a phase II enzyme inducer and induces the expression of the transcription factor Nrf2.
R-Sulforaphane is found naturally in cruciferous vegetables such as broccoli, and has been continuously studied for its health benefits, sometimes showing increased effectiveness compared to its synthetic R,S counterpart in various models.
1. Axelsson AS, Tubbs E, Rosengren AH, et al. “Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.“. Sci Transl Med. 2017 Jun 14;9(394).