β-cembrenediol ((1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol) is a diterpenoid that is isolated from the leaves of nicotiana tabacum (tobacco) plants. β-cembrenediol has been found to have neuro-protective effects in mice, reducing ischemic brain injury. The effect was found in both pre-treated and post-injury mice. It does this by increasing the phosphorylation of Akt, a well-known neuroprotective pathway. Additionally, β-cembrenediol and analogs have been found as anti-migratory compounds in wound healing assays with prostate cancer cells.
β-cembrenediol, and it’s C-4 epimer α-cembrenediol are in stock and available for research use.
Martins A. H. , Hu, J., et al. “Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and In vivo in Rodent Models of Brain Ischemia” Neuroscience. 2015, Apr 16; 291: 250-259. Doi: 10.1016/j.neuroscience.2015.02.001
Baraka, H. N., Khanfar, M. A., et al. “Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids” Planta Med 2011 Mar:77(5):467-476. Doi: 10.1055/s-0030-1250478.