Description
2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate) is an impurity of the chemotherapy drug paclitaxel. Is also known as paclitaxel impurity A or iso-cephalomannine.
Product Unit Size | Cost | Quantity | Stock |
---|
2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate) is an impurity of the chemotherapy drug paclitaxel. Is also known as paclitaxel impurity A or iso-cephalomannine.
Cas No. | 173101-54-7 |
---|---|
Purity | ≥95% |
Formula | C45H53NO14 |
Formula Wt. | 831.9 |
Chemical Name | 2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate) |
IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] (E)-2-methylbut-2-enoate |
Synonym | Paclitaxel 2-debenzoyl-2-(2-methyl-2-butenoate); Paclitaxel 2-debenzoyl pentenoate; iso-cephalomannine; paclitaxel impurity A |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.
Fermentation impurity
Vitamin B6 derivative, antioxidant.
Tetracycline; protein translation inhibitor, MM...
Endogenous amino acid, precursor of 5-HT and me...
Efflux pump inhibitor
Mycotoxin produced by Alternaria; topoisomerase...
Endogenous peptide hormone fragment, involved i...
Endogenous thyroid hormone T4.
Steroidal jerveratrum alkaloid found in Veratru...
Naturally occurring sesteterpenoid.
Synthesis impurity
Acyl transfer catalyst, involved in peptide syn...
Nucleoside (deoxyguanosine) analog, ganciclovir...
Diterpene found in brewed, unfiltered coffee; F...
Mycotoxin produced by species of Aspergillus; D...
Inhibitor of EGFR/HER2 (ErbB2).
Cyclic hexadepsipeptide mycotoxin produced by C...
Specific inhibitor of histone methyltransferase...
Protein translation inhibitor.
Dihydropyridine; L-type Ca2+ channel blocker.