A 83-01

Name: A 83-01
SKU: A001001
Availability: InStock

Product ID A001001

Cas No. 909910-43-6

Purity ≥98%

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Description

A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.

Product Info

Cas No.	909910-43-6
Purity	≥98%
Formula	C₂₅H₁₉N₅S
Formula Wt.	421.52
Chemical Name	3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
IUPAC Name	3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Synonym	A83-01; ALK5 Inhibitor IV; 1H-Pyrazole-1-carbothioamide,3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
Solubility	Soluble in DMSO 1mg/mL in ethanol 2.5mg/mL in ethyl acetate
Appearance	White to off-white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A001001 MSDS PDF
Info Sheet	A001001 Info Sheet PDF

References

Katsuda T, Kawamata M, Hagiwara K, et al. Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. PMID: 27840021.

Wang H, Liu S, Wang Y, et al. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016 Jan 14;16(2):126-131. PMID: 26773180.

Nishino Y, Murakami M, Funaba M. Expression and role of the TGF-beta family in glial cells infected with Borna disease virus. Microbes Infect. 2016 Feb;18(2):128-136. PMID: 26482505.

Ho YS, Tsai WH, Lin FC, et al. Cardioprotective actions of TGFbetaRI inhibition through stimulating autocrine/paracrine of survivin and inhibiting Wnt in cardiac progenitors. Stem Cells. 2016 Feb;34(2):445-455. PMID: 26418219.

Sun X, Kim YH, Phan TN, et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem. 2014;78(11):1805-1812. PMID: 25351330.

Nishino Y

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A 83-01

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