Description
AGI-6780 is an inhibitor of isocitrate dehydrogenase (IDH) that displays anticancer activity. This compound induces differentiation in acute myeloid leukemia (AML) and TF-1 erythroleukemia cells.
Product Unit Size | Cost | Quantity | Stock |
---|
AGI-6780 is an inhibitor of isocitrate dehydrogenase (IDH) that displays anticancer activity. This compound induces differentiation in acute myeloid leukemia (AML) and TF-1 erythroleukemia cells.
Cas No. | 1432660-47-3 |
---|---|
Purity | ≥98% |
Formula | C21H18F3N3O3S2 |
Formula Wt. | 481.51 |
IUPAC Name | N-Cyclopropyl-4-(3-thienyl)-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)benzenesulfonamide |
Synonym | AGI 6780, AGI6780 |
Solubility | DMSO 96 mg/mL (199.37 mM) Ethanol 96 mg/mL (199.37 mM) Water Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Lee WY, Chen KC, Chen HY, et al. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. Biomed Res Int. 2014;2014:364625. PMID: 24995286.
Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6. PMID: 23558173.
NSAID; COX-2 inhibitor.
Synthetic peptide fragment, prion protein analo...
Diterpene compound originally found in Rosmarin...
Triterpene saponin found in Panax; Kv7.1 K+ cha...
Pt-based DNA cross-linker.
Fluoroquinolone; topoisomerase IV and bacterial...
A third-generation ALK inhibitor.
Immunodominant peptide fragment of PLP, used to...
Captothecin derivative; topoisomerase I inhibit...
L-type Ca2+ channel blocker.
Statin; HMG-CoA reductase inhibitor.
Endogenous peptide, connects A and B chains of ...
Found in Astragalus membranaceus.
Synthetic steroid; glucocorticoid agonist.
Thiopurine antimetabolite; PRPP amidotransferas...
Synthetic steroid; glucocorticoid agonist.
Peptide hormone found in Solanaceae family plan...
Non-fluorescent halogenated A23187 analog, Ca2+...
Peptide, urocortin II analog; CRFR2 agonist.