AM251 is a cannabinoid receptor 1 (CB1) antagonist/inverse agonist. It works by inhibiting the action of the endocannabinoid system. AM251 shows beneficial effects as an anti-obesity compound. AM251 is renal-protective in rats fed a high-fat diet. Also, AM251 decreases expression of estrogen-related receptor alpha (EER α), a potential therapeutic target for obesity. AM251 also show beneficial effects for the impairment of fear memory in rats.