Description
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
Product Unit Size | Cost | Quantity | Stock |
---|
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
Cas No. | 164178-33-0 |
---|---|
Purity | ≥97% |
Formula | C23H25IN2O3 |
Formula Wt. | 504.37 |
Chemical Name | 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone |
IUPAC Name | [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone |
Synonym | AM 630, Iodopravadoline |
Solubility | 100mM in DMSO |
Appearance | White to off-white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Ross RA, Brockie HC, Stevenson LA, et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. PMID: 10188977
Patil M, Patwardhan A, Salas MM, et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology, 2011 Sep;61(4):778-88. PMID: 21645531.
Aspartyl protease inhibitor.
RAD51 inhibitor.
Found in milk and whey, cation and fatty acid c...
Polyether Ca2+ ionophore.
ATP-sensitive K+ channel activator, α-adrenerg...
Phosphodiesterase inhibitor that produces anti-...
Macrocycle
p110α PI3K inhibitor.
Protein translation inhibitor, peptidyl transfe...
Protonophore; chitinase OvCHT1 inhibitor.
Nitrofuran, livestock antibiotic.
5-α-Reductase inhibitor.
Tropane alkaloid found in Solanaceae plants; M1...
Glucose metabolism inhibitor, N-linked glycosyl...
ITC found in cruciferous vegetables.
Flavonol found in Tagetes.
Lck, Src, SIK inhibitor.
NSAID; COX-2 inhibitor.
Triterpene saponin found in species of Panax.
Found in Astragalus membranaceus.