Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
Cas No. | 1243243-89-1 |
---|---|
Purity | ≥98% |
Formula | C25H21N3O |
Formula Wt. | 379.45 |
Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
Synonym | Wnt-C59 |
Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
Aldosterone antagonist.
NSAID; COX-1/2 inhibitor.
Inhibitor of ALK2, ALK3, ALK6, and AMPK.
Imidazoline and α2-adrenergic agonist, Nav1.7 ...
Cap-dependent endonuclease inhibitor
Calcitonin-family peptide, involved in vasodila...
Secoiridoid glycoside found in Gentiana and Cep...
Endogenous peptide hormone inolved in gastric e...
Benzopyrone found in various plants, precursor ...
DHF reductase inhibitor.
Endogenous opioid peptide; μOR agonist.
NSAID; COX-2 inhibitor.
Potential ATP-sensitive K+ channel blocker, pot...
Taxane found in species of Taxus; potential mic...
Triterpene saponin found in species of Panax; Î...
Serine protease substrate/inhibitor.
PORCN inhibitor.
Cap-dependent endonuclease inhibitor
Cyclic sesquiterpene found in ginger root; pote...
Methoxy aminopropyl carbazole, neuroprotective....