Description
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Cas No. | 976-71-6 |
---|---|
Purity | ≥98% |
Formula | C22H28O3 |
Formula Wt. | 340.46 |
Chemical Name | (17α)-17-Hydroxy-3-oxo-pregna-4,6-diene-21- carboxylic acid γ-lactone |
IUPAC Name | 10,13-dimethylspiro[2,8,9,11,12,14,15, 16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione |
Synonym | Phanurane |
Melting Point | 149-151°C |
Appearance | Light yellow crystal powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Cargnelli G, Trevisi L, Debetto P, et al. Effects of canrenone on aorta and right ventricle of the rat. J Cardiovasc Pharmacol. 2001 May;37(5):540-7. PMID: 11336105.
Corvol P, Claire M, Oblin ME, et al. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. PMID: 7029118.
Derivative of aristolochic acid found in Asarum...
Furocoumarin; voltage-gated Na+ channel blocker...
Viral M2 proton channel blocker, MAO-A, NET, NM...
Protein synthesis inhibitor, DPP2 and metallope...
Selective inhibitor of c-Met.
Cannabinoid receptor 2 selective agonist.
p110α PI3K and mTOR inhibitor.
Somewhat selective in inhibiting COX-2 over COX...
γ-Secretase inhibitor.
Opioid neuropeptide; kyotorphin agonist.
Chloroethylnitrosourea, DNA alkylator and cross...
RET, EGFR, VEGFR2 inhibitor.
Flavonol found in various plant sources.
Syk inhibitor.
HIV protease inhibitor, SERCA inhibitor.
Flavone found in Passiflora, Oroxylum, and Pleu...
Vitamin B6 derivative, antioxidant.
Polyphenol derivative of caffeic acid found in ...
Tetracycline; protein translation inhibitor, MM...
TxA2 synthase inhibitor.