Description
CC-671 is a dual TTK/CLK2 inhibitor. It acts by inhibiting the phosphorylation of KNL1 and SRp75, direct substrates of TTK and CLK2. It is a monotherapy candidate for treatment of triple negative breast cancer.
Product Unit Size | Cost | Quantity | Stock |
---|
CC-671 is a dual TTK/CLK2 inhibitor. It acts by inhibiting the phosphorylation of KNL1 and SRp75, direct substrates of TTK and CLK2. It is a monotherapy candidate for treatment of triple negative breast cancer.
Cas No. | 1618658-88-0 |
---|---|
Purity | ≥98% |
Formula | C28H28N6O4 |
Formula Wt. | 512.57 |
IUPAC Name | 4-{[4-(Cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide |
Synonym | CC 671, CC671 |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Riggs J., Nagy M., et al. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem. 60(21):8989-9002 (2017). PMID: 28991472.
Zhu D., Xu S., et al. Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint. Mol Cancer Ther. 17(8):1727-38 (2018). PMID: 29866747.
mAChR antaonist.
Xanthine oxidase inhibitor.
β-lactam; penicillin binding protein inhibitor...
Benzimidazole; microtubule polymerization inhib...
Histamine H1 antagonist.
Synthetic catechol; ER agonist, microtubule pol...
Derivative of methyl caffeate, hydroxycinnamic ...
Polyether neurotoxin found in Karenia brevis; N...
Recombinant HIV glycoprotein antigen fragment.<...
D-amino acid, incorporated into bacterial cell ...
Glycopeptide, binds D-Ala-D-Ala; cell wall synt...
Lectin found in Canavelia, plant mitogen that b...
5-HT1A agonist, 5-HT2A antagonist.
Mycotoxin contaminant found in cereal grains.
Anthraquinone found in various plant sources; C...
Isoflavone found in Pueraria; 5-HT2C and GABA-A...
NSAID; TRPA1 agonist, COX-2 inhibitor.
Enalapril metabolite; ACE inhibitor.
Microtubule depolymerization inhibitor.
Endogenous neuropeptide, involved in nociceptio...