• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Cyclopamine

Cyclopamine

Product ID C9710
Cas No. 4449-51-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $85.20 In stock
25 mg $170.00 In stock
100 mg $472.60 In stock
500 mg $1,700.50 Please Inquire
1 g $2,764.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cyclopamine is a steroidal jerveratrum alkaloid found in Veratrum that binds Smo, inhibiting hedgehog (Shh) signaling pathways. Cyclopamine exhibits anticancer activity, decreases expression of Gli2 and Bcl-2, inhibiting proliferation and inducing apoptosis in adenoma cells and neuroblastoma cells.

CYCLOPAMINE SOLUBILITY: Ethanol is the best cyclopamine solvent for biological use.  A 2.8% solution (28 mg/mL) can be prepared by sonicating the cyclopamine in ethanol. Avoid over heating. Storage at -20 ºC is recommended. If cyclopamine crystallizes out of solution:  upon thawing, the mixture can be heated or sonicated again to redissolve the cyclopamine.
Methanol and DMSO can also be used as cyclopamine solvents, but solubility in methanol is much less (0.7 mg/mL).  Substantial heating is again needed to achieve solution with methanol or DMSO.

Product Info

Cas No.

4449-51-8

Purity

≥98%

Formula

C27H41NO2

Formula Wt.

411.62

Chemical Name

Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3- ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b- octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

IUPAC Name

(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10, 11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11, 11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7, 7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

Synonym

11-Deoxyjervine, 11-Deoxojervine, HSDB 3505.

Melting Point

212-215°C

Solubility

Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL). Soluble in DMSO & insoluble in water.

Appearance

White Crystalline Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9710 MSDS PDF

Info Sheet

C9710 Info Sheet PDF

Brochures

Cyclopamine Flyer

Hedgehog Signaling Flyer

WNT Booklet

References

Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • A2420

    A-769662

    AMPK activator.

    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%
  • M9356

    Myomodulin

    Proton pump inhibitor

    ≥95%
  • A4803

    Amantadine Sulfate

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • K4401

    KL-1 Peptide

    Peptide, c-Kit ligand fragment.

    ≥95%
  • U6801

    Urapidil

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • O0400

    Obatoclax

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥98%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • R2917

    Rhein

    Diacerein metabolite, anthraquinone found in Rh...

    ≥88%
  • C0264

    L-Carnitine Tartrate

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • M9645

    Myelin Oligodendrocyte Glycoprotein (35-55), rat

    Oligodendrocyte antigen used to induce EAE.

    ≥95%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • A985132

    AZD-8186

    Selective inhibitor of PI3Kβ and PI3Kδ.

    ≥99%
  • M1978

    S-(+)-Methoprene

    Juvenille insect growth hormone analog.

    ≥95%
  • T0393

    (+/-)-Taxifolin Hydrate

    Catechol-type flavonoid.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only