Description
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Product Unit Size | Cost | Quantity | Stock |
---|
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Cas No. | 1073154-85-4 |
---|---|
Purity | ≥98% |
Formula | C20H21F3N8O3S |
Formula Wt. | 510.49 |
IUPAC Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide |
Synonym | VS-6063, PF-04554878 |
Solubility | DMSO 5 mg/mL warmed (9.79 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Lee BY, Timpson P, Horvath LG, et al. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 2015 Feb;146C:132-149. PMID: 25316657.
Kang Y, Hu W, Ivan C, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. PMID: 24062525.
Found in Astragalus membranaceus.
Coccidiostat.
Type A trichothecene mycotoxin produced by Fusa...
β-lactam cephalosporin; penicillin binding pro...
Synthetic glycolipid found in Agelas mauritaniu...
5-HT1A partial agonist, SERT inhibitor.
Amino acid precursor of dopamine.
Voltage-gated Na+, Ca2+, K+ channel blocker, α...
MEK1/2 and ERK inhibitor.
inhibits inflammatory signaling
Synthetic peptide hormone.
Impurity of omeprazole
Endogenous adhesion molecule, binds PKC, calmod...
ALK, ROS1, c-MET inhibitor.
Heterocyclic light-emitting compound, natural l...
D-Seco Paclitaxel is an impurity in the product...