Description
Ensartinib is a third-generation ALK inhibitor. In addition, ensartinib is found to also have activity against ROS1, MET, SLK, Axl, LTK, ABL and EPHA2.
Product Unit Size | Cost | Quantity | Stock |
---|
Ensartinib is a third-generation ALK inhibitor. In addition, ensartinib is found to also have activity against ROS1, MET, SLK, Axl, LTK, ABL and EPHA2.
Cas No. | 1365267-27-1 |
---|---|
Purity | ≥98% |
Formula | C25H25Cl2FN6O3 |
Formula Wt. | 547.41 |
Chemical Name | 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide |
IUPAC Name | 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide |
Synonym | X396, X-396 |
Solubility | DMSO:100 mg/mL (178.11 mM) Ethanol:100 mg/mL (178.11 mM) Water:Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Horn L, Wakelee H, Reckamp KL, et al. MINI01.02: Response and plasma genotyping from phase I/II trial of ensartinib (X-396) in patients (pts) with ALK+ NSCLC: topic: medical oncology. J Thorac Oncol. 2016 Nov;11(11S)::S256-S257. PMID: 27969449
Caccese M, Ferrara R, Pilotto S, et al. Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice. Expert Opin Pharmacother. 2016 Dec;17(17):2253-2266. PMID: 27682212
Dholaria B, Hammond W, Shreders A, et al. Emerging therapeutic agents for lung cancer. J Hematol Oncol. 2016 Dec 9;9(1):138. PMID: 27938382
Triterpenoid
Endogenous amino acid, forms disulfide bridges ...
Triazole; 14-α demethylase inhibitor, potentia...
CDK1/2 inhibitor.
Cysteine-ITC conjugate, antioxidant; HDAC inhib...
Glycopeptide, binds D-Ala-D-Ala; cell wall synt...
Fermentation impurity
Thiopurine antimetabolite; PRPP amidotransferas...
ALK and Ros1 inhibitor, Trk antagonist.
NSAID; COX-1/2 inhibitor.
1-Naphthalenacetic acid derivative, NSAID; COX-...
Neuropeptide found in crustaceans and insects.<...
Syk inhibitor.
Major metabolite of ginsenosides Rb1, Rb2, Rc, ...
Serine protease substrate/inhibitor.
MEK1 inhibitor.
Induces ER degradation.
Protein translation inhibitor, peptidyl transfe...
Methylated derivative of n-octyl-caffeate.
Active metabolite of losartan