Description
PF-06447475 inhibits leucine-rich repeat kinase 2 (LRRK2), exhibiting neuroprotective activity. In animal models of Parkinson’s disease, this compound suppresses neuroinflammation and neurodegeneration.
Product Unit Size | Cost | Quantity | Stock |
---|
PF-06447475 inhibits leucine-rich repeat kinase 2 (LRRK2), exhibiting neuroprotective activity. In animal models of Parkinson’s disease, this compound suppresses neuroinflammation and neurodegeneration.
Cas No. | 1527473-33-1 |
---|---|
Purity | ≥98% |
Formula | C17H15N5O |
Formula Wt. | 305.13 |
Chemical Name | 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile |
IUPAC Name | 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile |
Solubility | DMSO 61 mg/mL Water Insoluble Ethanol Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Daher JP, Abdelmotilib HA, Hu X, et al. LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration. J Biol Chem. 2015 Jun 15. [Epub ahead of print]. PMID: 26078453.
Henderson JL, Kormos BL, Hayward MM, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. PMID: 25353650.
Aminoglycoside; protein translation inhibitor.<...
DAT inhibitor.
Coccidiostat; dihydrofolate reductase inhibitor...
GHB agonist, D2/3 antagonist.
Plasminogen inhibitor.
Aglycone isoflavone found in soy and red clover...
Diterpene found in Taxus.
Taxane found in Taxus; potential microtubule de...
2-methyl-1,4-naphthoquinone derivative
Tenoxicam impurity
Abl (T315I) inhibitor.
Bisphosphonate; inhibits transfer of farnesyl p...
Dibenzocyclooctadiene found in Schisandra.
Neuraminidase inhibitor.
BRD2/3/4 inhibitor.
Peptide; fibrinolysis inhibitor.
Peptide hormone found in Solanaceae family plan...
Oxidative phosphorylation inhibitor.
PARP inhibitor; potential Pim1 inhibitor.
Inhibitor of CDK.