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Vinorelbine Base

Vinorelbine Base

Product ID V3251
Cas No. 71486-22-1
Purity ≥90%
Unit SizeCostQuantityStock
1 mg $52.50 In stock
5 mg $187.30 In stock
25 mg $524.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vinorelbine is a semi-synthetic vinca alkaloid originally found in Catharanthus that exhibits anticancer chemotherapeutic activity. Vinorelbine binds β-tubulin and stimulates microtubule depolymerization, acting as an anti-mitotic. Vinorelbine is clinically used to treat breast cancer and non-small cell lung cancer (NSCLC). In osteosarcoma cells, vinorelbine downregulates expression of cyclin D1 and upregulates expression of p53, inhibiting cell growth.

Product Info

Cas No.

71486-22-1

Purity

≥90%

Formula

C45H54N4O8

Formula Wt.

778.93

Chemical Name

3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine

Synonym

Vinorelbine, NavelbineR, KW 2307, nor-5'-anhydrovinblastine, NVB

Appearance

Light brown powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V3251 MSDS PDF

Info Sheet

V3251 Info Sheet PDF

References

Capasso A. Vinorelbine in cancer therapy. Curr Drug Targets. 2012 Jul;13(8):1065-71. PMID: 22594474.

Roncuzzi L, Marti G, Baiocchi D, et al. Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. Oncol Rep. 2006 Jan;15(1):73-7. PMID: 16328036.

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