Description
Volitinib is an inhibitor of c-Met. It shows antitumor potential in models of gastric cancer. It is being investigated as a treatment for papillary renal cell carcinoma, where it has demonstrated an acceptable tolerability profile.
Product Unit Size | Cost | Quantity | Stock |
---|
Volitinib is an inhibitor of c-Met. It shows antitumor potential in models of gastric cancer. It is being investigated as a treatment for papillary renal cell carcinoma, where it has demonstrated an acceptable tolerability profile.
Cas No. | 1313725-88-0 |
---|---|
Purity | ≥98% |
Formula | C17H15N9 |
Formula Wt. | 345.37 |
Chemical Name | Volitinib |
IUPAC Name | 1-[(1S)-1-(Imidazo[1,2-a]pyridin-6-yl)ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine |
Synonym | Savolitinib, HMPL 504, HMPL0-504, HMPL504, AZD-6094, AZD 6094, AZD6094 |
Solubility | Insoluble in water. Solubility in DMSO - ~15 mg/mL. |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Gavine P., Ren Y., et al. Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models. Mol Oncol. 9(1):323-33 (2015). PMID: 25248999.
Gan H., Millward M., et al. First-in-Human Phase I Study of the Selective MET Inhibitor, Savolitinib, in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics and Anti-Tumor Activity. Clin Cancer Res. 2019. PMID: 30952639.
EGFR, VEGFR inhibitor.
Quinolone, antioxidant.
Monoterpene found in various plant sources.
mAChR agonist, selective for M2.
MEK1/2 and Raf inhibitor.
Antioxidant, vitamin E derivative found in vege...
PI3K inhibitor.
MAO-A/B inhibitor.
Cyclic peptide; calcineurin inhibitor.
Cephalomannine derivative found in Taxus; poten...
Fluoroquinolone; topoisomerase IV and bacterial...
PLK1 inhibitor.
PDGFR inhibitor.
Potential PKD binding agent.
Mycotoxin produced by species of Fusarium; pote...
All-trans nonaprenol isoprenoid, found in Solan...
Alpha blocker and vasoactive agent.
Synthetic peptide; dermorphin analog; δOR and ...
Lincosamide; ribosomal translocation and protei...
Synthetic vitamin E, antioxidant.