LKT Labs

Biochemicals for Life Science Research

Y27632 Dihydrochloride

Y27632 Dihydrochloride

Product ID Y1000
Cas No. 129830-38-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $92.00 In stock
5 mg $245.30 In stock
25 mg $714.70 In stock
Bulk Quote

Quicklinks

Description

Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK); Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF-β-related signaling. This compound exhibits neuroprotective and neuromodulatory activity, displaying benefit in animal models of Parkinson’s Disease and inhibiting conditioned place aversion in animal models of memory formation. Reduces dissociation-induced apoptosis in embryonic and neural stem cells. Increases stem cell cloning efficiency.

Product Info

Cas No.

129830-38-2
Purity

≥99%
Formula

C14H21N3O • 2HCl
Formula Wt.

320.26
IUPAC Name

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
Melting Point

286.2°C
Solubility

DMSO 64 mg/mL warmed (199.83 mM), water 14 mg/mL (43.71 mM)
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

Y1000 MSDS PDF
Info Sheet

Y1000 Info Sheet PDF

References

Rodriguez-Perez AI, Dominguez-Meijide A, Lanciego JL, et al. Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease. Neurobiol Dis. 2013 Oct;58:209-19. PMID: 23774254.

Wang J, Wang YH, Hou YY, et al. The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. Acta Pharmacol Sin. 2013 Jun;34(6):811-8. PMID: 23564082.

Zhang XH, Sun NX, Feng ZH, et al. Interference of Y-27632 on the signal transduction of transforming growth factor beta type 1 in ocular Tenon capsule fibroblasts. Int J Ophthalmol. 2012;5(5):576-81. PMID: 23166867.

Ishizaki T, Uehata M, Tamechika I, et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. PMID: 10779382.

Kuwahara K, Saito Y, Nakagawa O, et al. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett. 1999 Jun 11;452(3):314-8. PMID: 10386613.

Hirose M, Ishizaki T, Watanabe N, et al. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol. 1998 Jun 29;141(7):1625-36. PMID: 9647654.

Zhang L, Valdez J, et al. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011 Mar 28;6(3):e18271. PMID: 21464902

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • B8073

    4-tert-Butyl-5-Methoxycatechol

    BHA derivative.

    ≥98%
  • L0107

    Lactacystin

    Found in Streptomyces; proteasome inhibitor.

    ≥98%
  • L8009

    D-Luciferin 1-(4,5-dimethoxy-2-nitrophenyl) Ethyl Ester

    Cell-membrane permeable heterocyclic light-emit...

    ≥95%
  • A7200

    AS-252424

    p110γ PI3K inhibitor, potential TRPC1/5/6 nega...

    ≥98%
  • D364086

    Decernotinib

    JAK3 inhibitor.

    ≥99%
  • H2980

    Humanin, human

    Endogenous peptide; FPRL1/2 agonist.

    ≥95%
  • C5645

    Colchicine

    Found in Colchicum; microtubule polymerization ...

    ≥97%
  • S8248

    Sulfamethoxazole

    Sulfonamide; PABA inhibitor.

    ≥98%
  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%
  • T0110

    Taxane Standard Mixture

    Mixture of taxanes.

    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhib...

    ≥98%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • L0209

    Lactoferrin, cow

    Endogenous glycoprotein; lactoferrin agonist.

    ≥92%
  • B5874

    Bosutinib

    Src and Abl inhibitor.

    ≥98%
  • F130280

    FHD-286

    BRG1/BRM ATPase inhibitor

    ≥98%
  • G124084

    GDC-0973

    MEK1 inhibitor.

    ≥99%
  • N1979

    Neuromedin

    Endogenous proneurotensin peptide, involved in ...

    ≥95%
  • C5768

    Corazonin

    Neuropeptide found in insects.

    ≥95%